Introduction：Basic information about CAS 36507-31-0|2-(4-Methyl-1H-imidazol-5-yl)ethanamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-(4-Methyl-1H-imidazol-5-yl)ethanamine |
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| CAS Number | 36507-31-0 | Molecular Weight | 125.17 |
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| Density | 1.1g/cm3 | Boiling Point | 345ºC at 760mmHg |
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| Molecular Formula | C6H11N3 | Melting Point | / |
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| MSDS | / | Flash Point | 189.3ºC |
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Names
| Name | 4-methylhistamine |
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| Synonym | More Synonyms |
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2-(4-Methyl-1H-imidazol-5-yl)ethanamine BiologicalActivity
| Description | 4-Methylhistamine is a potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor |
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| References | [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349. [2]. Kim CH, et al. Inhibitory Effect of Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice by Histamine H4 Receptor Agonist 4-Methylhistamine. Scand J Immunol. 2016 Jun;83(6):409-17. |
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Chemical & Physical Properties
| Density | 1.1g/cm3 |
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| Boiling Point | 345ºC at 760mmHg |
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| Molecular Formula | C6H11N3 |
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| Molecular Weight | 125.17 |
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| Flash Point | 189.3ºC |
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| Exact Mass | 125.09500 |
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| PSA | 54.70000 |
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| LogP | 0.91960 |
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| InChIKey | UGYXPZQILZRKJJ-UHFFFAOYSA-N |
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| SMILES | Cc1[nH]cnc1CCN |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NI3505600
- CHEMICAL NAME :
- Imidazole, 4-(2-aminoethyl)-5-methyl-
- CAS REGISTRY NUMBER :
- 36507-31-0
- LAST UPDATED :
- 198708
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C6-H11-N3
- MOLECULAR WEIGHT :
- 125.20
- WISWESSER LINE NOTATION :
- T5M CNJ D2Z E1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Cells - not otherwise specified
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- Volume(issue)/page/year: 65,400,1975
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933290090 |
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Customs
| HS Code | 2933290090 |
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| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-Methylhistamine |
| 4-(2-aminoethyl)-5-methyl-1H-imidazole |
| 2-(5-methyl-1(3)H-imidazol-4-yl)-ethylamine |
| 2-(5-methyl-1H-imidazol-4-yl)ethanamine |
| 5-Methylhistamine |
| 2-(5-methyl-1H-imidazol-4-yl)-ethylamine |
| 5(4)-Methylhistamine |
| 1H-Imidazo-4-ethanamine,5-methyl |
| 2-(5-methyl-4-imidazolyl)ethylamine |
| IMIDAZOLE,4-(2-AMINOETHYL)-5-METHYL |
| 1H-Imidazole-4-ethanamine,5-methyl |
| 2-(5-Methyl-1(3)H-imidazol-4-yl)-aethylamin |
