CAS 4488-22-6|UNII:TL35μ1249

Introduction：Basic information about CAS 4488-22-6|UNII:TL35μ1249, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. UNII:TL35μ1249 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	UNII:TL35μ1249
CAS Number	4488-22-6	Molecular Weight	284.35
Density	1.3±0.1 g/cm3	Boiling Point	480.8±30.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₆N₂	Melting Point	242-244ºC(lit.)
MSDS	ChineseUSA	Flash Point	293.9±24.0 °C
Symbol	GHS05, GHS07	Signal Word	Danger

Names

Name	[1,1'-Binaphthalene]-2,2'-diamine
Synonym	More Synonyms

UNII:TL35μ1249 BiologicalActivity

Description	1,1'-Binaphthyl-2,2'-diamine is the inactive isomer of (S)-[1,1'-Binaphthalene]-2,2'-diamine (HY-W007978A), and can be used as an experimental control. (S)-[1,1'-Binaphthalene]-2,2'-diamine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	480.8±30.0 °C at 760 mmHg
Melting Point	242-244ºC(lit.)
Molecular Formula	C₂₀H₁₆N₂
Molecular Weight	284.35
Flash Point	293.9±24.0 °C
Exact Mass	284.131348
PSA	52.04000
LogP	3.85
Appearance of Characters	slightly beige
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.775
InChIKey	DDAPSNKEOHDLKB-UHFFFAOYSA-N
SMILES	Nc1ccc2ccccc2c1-c1c(N)ccc2ccccc12
Water Solubility	Insoluble in water

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU3090000

CHEMICAL NAME :: (1,1'-Binaphthalene)-2,2'-diamine

CAS REGISTRY NUMBER :: 4488-22-6

BEILSTEIN REFERENCE NO. :: 2138401

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H16-N2

MOLECULAR WEIGHT :: 284.38

WISWESSER LINE NOTATION :: L66J CZ B- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 mg/kg/27W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

REFERENCE :: AJCAA7 American Journal of Cancer. (New York, NY) V.15-40, 1931-40. For publisher information, see CNREA8. Volume(issue)/page/year: 40,62,1940

Safety Information

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H302-H318
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	36/37/38-41-22
Safety Phrases	S26;S39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DU3090000

Synonyms

2,2'-diamino-1,1'-binaphthalene

UNII:TL35μ1249

1,1'-Binaphthalene-2,2'-diamine

1,1-BINAPHY1-2,2'-DIAMINE

(S)-1,1'-binaphthyl-2,2'-diamine

binaphthyldiamine

rac-1,1'-binaphthyl-2,2'-diamine

MFCD00145204

S(-)-DABN

2,2-DIAMINO-1,1'-BINAPHTHALENE

(R)-(+)-1,1'-binaphthyl-2,2'-diamine

R(+)-DABN

1,1'-Bi[naphthalene-2-amine]

1,1'-Binaphthyl-2,2'-diamine

(+)-2,2'-diamino-1,1-binaphthyl

1,1'-Bi(2-naphthalenamine)

[1,1'-Binaphthalene]-2,2'-diamine

Recommended......