CAS 138-65-8|Norepinephrine

Introduction：Basic information about CAS 138-65-8|Norepinephrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
4. Safety Information
5. Customs
6. Synonyms

Common Name	Norepinephrine
CAS Number	138-65-8	Molecular Weight	169.178
Density	1.4±0.1 g/cm3	Boiling Point	442.6±40.0 °C at 760 mmHg
Molecular Formula	C₈H₁₁NO₃	Melting Point	-190ºC (dec.)
MSDS	/	Flash Point	221.5±27.3 °C

Names

Name	noradrenaline
Synonym	More Synonyms

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	442.6±40.0 °C at 760 mmHg
Melting Point	-190ºC (dec.)
Molecular Formula	C₈H₁₁NO₃
Molecular Weight	169.178
Flash Point	221.5±27.3 °C
Exact Mass	169.073898
PSA	86.71000
LogP	-0.88
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.659
InChIKey	SFLSHLFXELFNJZ-UHFFFAOYSA-N
SMILES	NCC(O)c1ccc(O)c(O)c1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DN6300000

CHEMICAL NAME :: Benzyl alcohol, alpha-(aminomethyl)-3,4-dihydroxy-, (+-)-

CAS REGISTRY NUMBER :: 138-65-8

LAST UPDATED :: 199106

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H11-N-O3

MOLECULAR WEIGHT :: 169.20

WISWESSER LINE NOTATION :: Z1YQR CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 130 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 68,501,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,64,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4700 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 95,502,1949

Safety Information

Hazard Codes	T+: Very toxic;
Risk Phrases	R28
Safety Phrases	S28;S45;S36/S37/S39
WGK Germany	3
RTECS	DN6300000
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

1-(3,4-Dihydroxy)phenyl-2-aminoethanol

(-)-NORADRENALINE

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-(-)-

4-[(1R)-2-amino-1-hydroxyéthyl]benzène-1,2-diol

L-NOREPINEPHRINE

(+)-Norepinephrin

4-((R)-2-Amino-1-hydroxy-ethyl)-benzene-1,2-diol

1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-

(R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol

EINECS 205-337-9

4-(1-Hydroxy-2-aminoethyl)catechol

R-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol

norepinephrinum [INN_la]

noradrenaline

DL-ARTERENOL

1,2-Benzenediol, 4-((R)-2-amino-1-hydroxyethyl)-

[3H]-(+/-)-Norepinephrine

3,4-Dhydroxyphenylethanolamine

L-NORADRENALINE

(R)-(-)-norepinephrine

DL-NOREPINEPHRINE

(+/-)-Norepinephrine

(-)-a-(Aminomethyl)protocatechuyl alcohol

4-[(1R)-2-Amino-1-hydroxyethyl]benzol-1,2-diol

Noradrenalin

[14C]-(+/-)-Norepinephrine

(-)-norepinephrine

(R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol

(R)-norepinephrine

Racemic norepinephrine

(R)-noradrenaline

4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol

MFCD00066505

(-)-(R)-Norepinephrine

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-

DL-Noradrenaline

4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol

4-[(1RS)-2-amino-1-hydroxyethyl]-1,2-benzenediol

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