CAS 476-28-8|(-)-Lycorine

Introduction：Basic information about CAS 476-28-8|(-)-Lycorine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Lycorine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	(-)-Lycorine
CAS Number	476-28-8	Molecular Weight	287.310
Density	1.5±0.1 g/cm3	Boiling Point	477.4±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₇NO₄	Melting Point	253-255ºC (dec.)
MSDS	/	Flash Point	242.5±28.7 °C

Names

Name	lycorine
Synonym	More Synonyms

(-)-Lycorine BiologicalActivity

Description	Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant family with antiviral, antimalarial and antiinflammation activities. Lycorine inhibits the growth and metastasis of hormone-refractory anti-prostate cancer (PCa) and induces cell apoptosis[1].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer
In Vitro	Lycorine inhibits cell proliferation in a dose-dependent manner in the abovementioned 4 PCa cell lines, and the IC50 ranged from 5 μM to 10 μM., it also shows Lycorine has little effects on PNT1A cell's proliferation[1].
References	[1]. Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun 20;6(17):15348-61.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	477.4±45.0 °C at 760 mmHg
Melting Point	253-255ºC (dec.)
Molecular Formula	C₁₆H₁₇NO₄
Molecular Weight	287.310
Flash Point	242.5±28.7 °C
Exact Mass	287.115753
PSA	62.16000
LogP	0.77
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.733
InChIKey	XGVJWXAYKUHDOO-DANNLKNASA-N
SMILES	OC1C=C2CCN3Cc4cc5c(cc4C(C1O)C23)OCO5

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2900000

CHEMICAL NAME :: Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-

CAS REGISTRY NUMBER :: 476-28-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H17-N-O4

MOLECULAR WEIGHT :: 287.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),23S,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),23S,1960

Safety Information

Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Class	9.0

Synonyms

3,3a-Didehydrolycoran-1a,2b-diol

Amarylline

(1a,2b)-3,12-Didehydro-9,10-[methylenebis(oxy)]galanthan-1,2-diol

(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-

Lycorine

(1S,2S,12bS,12cS)-1,2-diol-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine

Galanthidine

Belamarine

Licorine

Narcissine

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