CAS 135-16-0|L-5,6,7,8-Tetrahydrofolic acid
Introduction：Basic information about CAS 135-16-0|L-5,6,7,8-Tetrahydrofolic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | L-5,6,7,8-Tetrahydrofolic acid | ||
|---|---|---|---|
| CAS Number | 135-16-0 | Molecular Weight | 445.42900 |
| Density | 1.7g/cm3 | Boiling Point | 555.12°C (rough estimate) |
| Molecular Formula | C19H23N7O6 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 5,6,7,8-tetrahydrofolic acid |
|---|---|
| Synonym | More Synonyms |
L-5,6,7,8-Tetrahydrofolic acid BiologicalActivity
| Description | L-5,6,7,8-Tetrahydrofolic acid, a folic acid derivative, which is a coenzyme in many reactions, especially in the metabolism of amino acids and nucleic acids. |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Metabolic Disease |
| Target | Human Endogenous Metabolite |
Chemical & Physical Properties
| Density | 1.7g/cm3 |
|---|---|
| Boiling Point | 555.12°C (rough estimate) |
| Molecular Formula | C19H23N7O6 |
| Molecular Weight | 445.42900 |
| Exact Mass | 445.17100 |
| PSA | 211.56000 |
| LogP | 1.03910 |
| Appearance of Characters | powder | off-white to tan |
| Index of Refraction | 1.762 |
| InChIKey | MSTNYGQPCMXVAQ-KIYNQFGBSA-N |
| SMILES | Nc1nc2c(c(=O)[nH]1)NC(CNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)CN2 |
| Storage condition | −20°C |
| Stability | We have observed that this material decomposes steadily over time. Use immediately upon receipt. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 18 gm/kg/5W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - normocytic anemia
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1104,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6 gm/kg/6D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1128,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 46800 mg/kg/26W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1114,1973 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 8-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - physical
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 7-13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 7,1132,1973
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | MA0600800 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Tetrahydrofolic acide |
| Tetrahydropteroylglutaamic acid |
| (6S)-Tetrahydrofolic acid |
| l-amino)benzoyl) |
| TETRAHYDROFOLIC ACID |
| EINECS 205-181-1 |
| 5,6,7,8-tetrahydrofolicacid |
| L-5,6,7,8-Tetrahydrofolic acid |
| MFCD00135583 |
| (6S)-Thfa |
| tetrahydropteroylglutamicacid |
| (6R,6S)-tetrahydrofolic acid |
| (6RS)-5,6,7,8-Tetrahydro-L-folsaeure |
