Introduction：Basic information about CAS 39800-16-3|4-Hydroperoxy cyclophosphamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-Hydroperoxy cyclophosphamide |
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| CAS Number | 39800-16-3 | Molecular Weight | 293.08500 |
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| Density | 1.465g/cm3 | Boiling Point | 419.946ºC at 760 mmHg |
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| Molecular Formula | C7H15Cl2N2O4P | Melting Point | 100-103ºC |
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| MSDS | / | Flash Point | 207.776ºC |
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Names
| Name | 4-hydroperoxycyclophosphamide |
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| Synonym | More Synonyms |
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4-Hydroperoxy cyclophosphamide BiologicalActivity
| Description | 4-Hydroperoxy cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide is used to treat lymphomas and autoimmune disorders. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisSignaling Pathways >>Cell Cycle/DNA Damage >>DNA Alkylator/Crosslinker |
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Chemical & Physical Properties
| Density | 1.465g/cm3 |
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| Boiling Point | 419.946ºC at 760 mmHg |
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| Melting Point | 100-103ºC |
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| Molecular Formula | C7H15Cl2N2O4P |
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| Molecular Weight | 293.08500 |
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| Flash Point | 207.776ºC |
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| Exact Mass | 292.01500 |
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| PSA | 80.84000 |
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| LogP | 2.02850 |
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| Index of Refraction | 1.525 |
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| InChIKey | VPAWVRUHMJVRHU-UHFFFAOYSA-N |
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| SMILES | O=P1(N(CCCl)CCCl)NC(OO)CCO1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RP5900000
- CHEMICAL NAME :
- 2H-1,3,2-Oxazophosphorine, 2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-, 2-oxide
- CAS REGISTRY NUMBER :
- 39800-16-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C7-H15-Cl2-N2-O4-P
- MOLECULAR WEIGHT :
- 293.11
- WISWESSER LINE NOTATION :
- T6MPOTJ BN2G2G FOQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 76040 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 35,1163,1986
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Synonyms
| PERFOSFAMIDE |
| ASTA 6496 |
| 4-Hydroperoxycyclofosfamide |
| 4-Hydroperoxycyclophosphamide |
| 4-OOH Cyclophosphamide |
| N,N-bis(2-chloroethyl)-4-hydroperoxy-2-oxo-1,3,2λ<sup>5</sup>-oxazaphosphinan-2-amine |
| Perfosphamide |
| 4-Hydroperoxy-cyclophosphamid |
