Introduction：Basic information about CAS 927691-21-2|PQ-10, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PQ-10 |
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| CAS Number | 927691-21-2 | Molecular Weight | 403.43400 |
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| Density | 1.333 | Boiling Point | / |
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| Molecular Formula | C28H39N5O3 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | 6,7-dimethoxy-4-(3-quinoxalin-2-yloxypyrrolidin-1-yl)quinazoline |
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| Synonym | More Synonyms |
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PQ-10 BiologicalActivity
| Description | PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Neurological Disease |
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| Target | PDE10A:4.6 nM (IC50) |
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| In Vivo | PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice[1]. Animal Model: 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice[1] Dosage: 0.16, 0.63, 2.5, and 10 mg/kg Administration: s.c. Result: Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice. |
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| References | [1]. Dedeurwaerdere S, et al. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker. J Pharmacol Exp Ther. 2011;339(1):210-217. |
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Chemical & Physical Properties
| Density | 1.333 |
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| Molecular Formula | C28H39N5O3 |
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| Molecular Weight | 403.43400 |
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| Exact Mass | 403.16400 |
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| PSA | 82.49000 |
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| LogP | 3.31290 |
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| InChIKey | UBIIFKJMNRPNMT-UHFFFAOYSA-N |
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| SMILES | COc1cc2ncnc(N3CCC(Oc4cnc5ccccc5n4)C3)c2cc1OC |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
