Introduction：Basic information about CAS 34175-96-7|Pterosin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pterosin B |
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| CAS Number | 34175-96-7 | Molecular Weight | 218.292 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 396.5±41.0 °C at 760 mmHg |
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| Molecular Formula | C14H18O2 | Melting Point | / |
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| MSDS | / | Flash Point | 169.3±20.2 °C |
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Names
| Name | (R)-6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one |
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| Synonym | More Synonyms |
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Pterosin B BiologicalActivity
| Description | Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>Salt-inducible Kinase (SIK) |
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| Target | SIK3 |
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| References | [1]. Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325. [2]. Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 396.5±41.0 °C at 760 mmHg |
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| Molecular Formula | C14H18O2 |
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| Molecular Weight | 218.292 |
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| Flash Point | 169.3±20.2 °C |
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| Exact Mass | 218.130676 |
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| PSA | 37.30000 |
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| LogP | 2.65 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.560 |
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| InChIKey | SJNCSXMTBXDZQA-SECBINFHSA-N |
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| SMILES | Cc1cc2c(c(C)c1CCO)C(=O)C(C)C2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NK7537730
- CHEMICAL NAME :
- 1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)-
- CAS REGISTRY NUMBER :
- 34175-96-7
- LAST UPDATED :
- 198703
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C14-H18-O2
- MOLECULAR WEIGHT :
- 218.32
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Human HeLa cell
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,829,1975
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2914400090 |
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Customs
| HS Code | 2914400090 |
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| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 1-Indanone, 6-(2-hydroxyethyl)-2,5,7-trimethyl-, (-)- |
| 6-(2-hydroxyethyl)-2,5,7-trimethyl-2,3-dihydro-1H-inden-1-one |
| 1H-Inden-1-one, 2,3-dihydro-6-(2-hydroxyethyl)-2,5,7-trimethyl- |
| 6-(2-Hydroxyethyl)-2,5,7-trimethyl-1-indanone |
| Pterosin B |
