CAS 134564-82-2|Befloxatone

Introduction：Basic information about CAS 134564-82-2|Befloxatone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Befloxatone BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Befloxatone
CAS Number	134564-82-2	Molecular Weight	349.30200
Density	1.326g/cm3	Boiling Point	447.3ºC at 760mmHg
Molecular Formula	C₁₅H₁₈F₃NO₅	Melting Point	/
MSDS	/	Flash Point	224.3ºC

Names

Name	(5R)-5-(methoxymethyl)-3-[4-[(3R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl]-1,3-oxazolidin-2-one
Synonym	More Synonyms

Befloxatone BiologicalActivity

Description	Befloxatone (MD-370503) is an orally active, selective and reversible inhibitor of Monoamine Oxidase A (MAO-A) (IC50=4 nM). Befloxatone increases the tissue level of monoamine, striatal dopamine and cortical norepinephrine. Befloxatone has antidepressant potential[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease
Target	MAO-A:4 nM (IC50) MAO-B:300 nM (IC50)
In Vitro	Befloxatone (100 nM; 0-100 min) 可逆抑制大鼠脑匀浆中的 MAO-A 活性，60 min 后不再发挥抑制作用[1]。
In Vivo	Befloxatone (0.75 mg/kg; i.p.; single dose) 在大鼠中增加单胺的组织水平，并降低其脱氨基代谢物的水平[1]。 Befloxatone (1 mg/kg; i.p.; single dose) 可诱导大鼠细胞外纹状体多巴胺和皮质去甲肾上腺素水平升高，但不诱导皮质 5-羟色胺水平升高[1]。 Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) 在大鼠中有效抑制血清素能神经元的放电速率，部分降低去甲肾上腺素能神经元的发射，对多巴胺能神经元的激发没有影响[1]。 Befloxatone (1.5 mg/kg; p.o.; single dose) 在大鼠中不会增强中心活性剂量口服酪胺的升压作用，具有广泛的安全性[1]。
References	[1]. Curet O, et al. Preclinical profile of befloxatone, a new reversible MAO-A inhibitor. J Affect Disord. 1998 Dec;51(3):287-303.

Chemical & Physical Properties

Density	1.326g/cm3
Boiling Point	447.3ºC at 760mmHg
Molecular Formula	C₁₅H₁₈F₃NO₅
Molecular Weight	349.30200
Flash Point	224.3ºC
Exact Mass	349.11400
PSA	68.23000
LogP	2.41530
Vapour Pressure	8.73E-09mmHg at 25°C
Index of Refraction	1.498
InChIKey	IALVDLPLCLFBCF-CHWSQXEVSA-N
SMILES	COCC1CN(c2ccc(OCCC(O)C(F)(F)F)cc2)C(=O)O1

Synonyms

UNII-4H75PAD8M3

(R)-5-(methoxymethyl)-3-(p[(R)-4,4,4-trifluoro-3-hydroxybutoxy]phenyl)-2-oxazolidinone

BEFLOXATONE

(R)-5-(methoxymethyl)-3-(4-((R)-4,4,4-trifluoro-3-hydroxybutoxy)phenyl)-oxazolidin-2-one

Befloxatone (INN)

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