Introduction：Basic information about CAS 13071-11-9|(R)-Propranolol hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (R)-Propranolol hydrochloride |
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| CAS Number | 13071-11-9 | Molecular Weight | 295.80400 |
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| Density | / | Boiling Point | 434.9ºC at 760 mmHg |
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| Molecular Formula | C16H22ClNO2 | Melting Point | 196-198 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 216.8ºC |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | dexpropranolol hydrochloride |
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| Synonym | More Synonyms |
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(R)-Propranolol hydrochloride BiologicalActivity
| Description | (R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
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| In Vivo | Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane, but the mean dose of (-)-propranolol is 0.09 mg/kg whereas that of (+)-propranolol is 4.2 mg/kg[1]. Both isomers of propranolol are capable of reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs. The dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[1]. (R)-Propranolol hydrochloride (10 mg/kg) has no antagonistic activity in rats, the cardiac responses to isoprenaline of rat can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[1]. |
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| References | [1]. A M Barrett,et al. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol |
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Chemical & Physical Properties
| Boiling Point | 434.9ºC at 760 mmHg |
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| Melting Point | 196-198 °C(lit.) |
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| Molecular Formula | C16H22ClNO2 |
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| Molecular Weight | 295.80400 |
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| Flash Point | 216.8ºC |
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| Exact Mass | 295.13400 |
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| PSA | 41.49000 |
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| LogP | 3.77040 |
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| Vapour Pressure | 2.48E-08mmHg at 25°C |
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| InChIKey | ZMRUPTIKESYGQW-PFEQFJNWSA-N |
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| SMILES | CC(C)NCC(O)COc1cccc2ccccc12.[Cl-].[H+] |
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| Storage condition | 2-8°C |
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| Water Solubility | ethanol: 10 mg/mL |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R22 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| HS Code | 2922509090 |
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Customs
| HS Code | 2922509090 |
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| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles1
More Articles
| Effects on feeding rate and biomarker responses of marine mussels experimentally exposed to propranolol and acetaminophen. Anal. Bioanal. Chem 396 , 649-56, (2010) Environmental risk assessments of human pharmaceuticals and other 'emerging contaminants' should integrate both population-relevant endpoints and biomarkers of potential modes of action in a range of ... | |
Synonyms
| EINECS 235-961-7 |
| MFCD00066275 |
| (R)-(+)-PROPRANOLOL |
| (R)-Propranolol Hydrochloride |
