CAS 774549-97-2|KM 11060

Introduction：Basic information about CAS 774549-97-2|KM 11060, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. KM 11060 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles1
7. Synonyms

Common Name	KM 11060
CAS Number	774549-97-2	Molecular Weight	422.328
Density	1.5±0.1 g/cm3	Boiling Point	607.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇Cl₂N₃O₂S	Melting Point	/
MSDS	ChineseUSA	Flash Point	321.1±34.3 °C
Symbol	GHS06	Signal Word	Danger

Names

Name	7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
Synonym	More Synonyms

KM 11060 BiologicalActivity

Description	KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>CFTRResearch Areas >>Endocrinology
References	[1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89. [2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.

Description

KM11060 is a novel corrector of the F508del-CFTR trafficking defect.Target: CFTRin vitro: Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. KM11060 rescues F508del-CFTR trafficking in cultured cells and native epithelial tissues. KM11060 partially corrects F508del-CFTR processing and increases surface expression to 75% of that observed in cells incubated at low temperature. Up to 50% of the F508del-CFTR in cells treated with KM11060 was complex-glycosylated, indicating passage through the Golgi. KM11060 as a promising compound for further development of CF therapeutics. [1]in vivo: In LPS-induced acute lung inflammation, blockade of PSGL-1 (P-selectin glycoprotein ligand-1) or P-selectin, antagonism of PAF by WEB2086, or correction of mutated CFTR trafficking by KM11060 could significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice. [2]

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>CFTRResearch Areas >>Endocrinology

References

[1]. Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.

[2]. Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	607.3±65.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₇Cl₂N₃O₂S
Molecular Weight	422.328
Flash Point	321.1±34.3 °C
Exact Mass	421.041840
PSA	61.89000
LogP	4.19
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.676
InChIKey	GIEHIZKCIZLXLF-UHFFFAOYSA-N
SMILES	O=S(=O)(c1ccc(Cl)cc1)N1CCN(c2ccnc3cc(Cl)ccc23)CC1
Storage condition	2-8℃

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
RIDADR	UN 2811 6.1 / PGIII
HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles1

Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice.

PLoS ONE 8 , e82683, (2013)

Mutation of CFTR (cystic fibrosis transmembrane conductance regulator) leads to cystic fibrosis (CF). Patients with CF develop abnormalities of blood platelets and recurrent lung inflammation. However...

Synonyms

7-Chloro-4-{4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl}quinoline

Quinoline, 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-

7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazin-1-yl}quinoline

7-chloro-4-{4-[(4-chlorophenyl)sulfonyl]piperazino}quinoline

KM 11060

KM11060

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