CAS 781652-57-1|CDPPB
| Common Name | CDPPB | ||
|---|---|---|---|
| CAS Number | 781652-57-1 | Molecular Weight | 364.39900 |
| Density | 1.203g/cm3 | Boiling Point | 523.277ºC at 760 mmHg |
| Molecular Formula | C23H16N4O | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 270.268ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 3-cyano-N-(2,5-diphenylpyrazol-3-yl)benzamide |
|---|---|
| Synonym | More Synonyms |
CDPPB BiologicalActivity
| Description | CDPPB is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
| Target | mGluR5:27 nM (EC50) |
| References | [1]. Kinney GG, et, al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J Pharmacol Exp Ther. 2005 Apr; 313(1):199-206. |
Chemical & Physical Properties
| Density | 1.203g/cm3 |
|---|---|
| Boiling Point | 523.277ºC at 760 mmHg |
| Molecular Formula | C23H16N4O |
| Molecular Weight | 364.39900 |
| Flash Point | 270.268ºC |
| Exact Mass | 364.13200 |
| PSA | 70.71000 |
| LogP | 4.73628 |
| Index of Refraction | 1.655 |
| InChIKey | BKUIZWILNWHFHD-UHFFFAOYSA-N |
| SMILES | N#Cc1cccc(C(=O)Nc2cc(-c3ccccc3)nn2-c2ccccc2)c1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles8
More Articles| Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J. Neurosci. 34(22) , 7562-74, (2014) Addiction is a chronic relapsing disorder in which relapse is often initiated by exposure to drug-related cues. The present study examined the effects of mGluR5 activation on extinction of ethanol-cue... | |
| The mGluR5 positive allosteric modulator, CDPPB, ameliorates pathology and phenotypic signs of a mouse model of Huntington's disease. Neurobiol. Dis. 73 , 163-73, (2014) Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the amino-terminal region of the huntingtin protein (htt), leading to motor dysfunc... | |
| Therapeutic effects of metabotropic glutamate receptor 5 positive allosteric modulator CDPPB on phencyclidine-induced cognitive deficits in mice. Fundam. Clin. Pharmacol. 27(5) , 483-8, (2013) This study was undertaken to examine the effects of CDPPB (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide), a positive allosteric modulator (PAM) of metabotropic glutamate receptor 5 (mGlu₅), on co... |
Synonyms
| mGluR5 Ligand,CDPPB |
| CDPPB |
