Introduction：Basic information about CAS 2529-45-5|Flurogestone Acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Flurogestone Acetate |
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| CAS Number | 2529-45-5 | Molecular Weight | 406.488 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 526.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C23H31FO5 | Melting Point | 267.5ºC |
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| MSDS | / | Flash Point | 272.3±30.1 °C |
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Names
| Name | Flugestone 17-Acetate |
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| Synonym | More Synonyms |
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Flurogestone Acetate BiologicalActivity
| Description | Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorResearch Areas >>Endocrinology |
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| References | [1]. Freitas VJ, et al. Estrus synchronization in dairy goats: use of fluorogestone acetate vaginal sponges or norgestomet ear implants. Anim Reprod Sci. 1997 Apr;46(3-4):237-44. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 526.7±50.0 °C at 760 mmHg |
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| Melting Point | 267.5ºC |
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| Molecular Formula | C23H31FO5 |
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| Molecular Weight | 406.488 |
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| Flash Point | 272.3±30.1 °C |
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| Exact Mass | 406.215546 |
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| PSA | 80.67000 |
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| LogP | 1.93 |
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| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
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| Index of Refraction | 1.548 |
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| InChIKey | JKQQZJHNUVDHKP-FQJIPJFPSA-N |
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| SMILES | CC(=O)OC1(C(C)=O)CCC2C3CCC4=CC(=O)CCC4(C)C3(F)C(O)CC21C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TU5024000
- CHEMICAL NAME :
- Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17-dihydroxy-, 17-acetate
- CAS REGISTRY NUMBER :
- 2529-45-5
- BEILSTEIN REFERENCE NO. :
- 3123549
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C23-H31-F-O5
- MOLECULAR WEIGHT :
- 406.54
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ A1 BF CQ E1 FV1 FOV1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 158 ug/kg
- SEX/DURATION :
- female 19 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Fertility - other measures of fertility Reproductive - Effects on Newborn - other neonatal measures or effects
- REFERENCE :
- JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 22,515,1970
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Synonyms
| Flurogestone Acetate |
| [(8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
| EINECS 219-776-9 |
| 9-Fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione 17-acetate |
| 9-Fluoro-11b,17-dihydroxyprogesterone 17-Acetate |
| Progesterone, 9-fluoro-11β,17-dihydroxy-, 17-acetate |
| Pregn-4-ene-3,20-dione, 17-(acetyloxy)-9-fluoro-11-hydroxy-, (11β)- |
| Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17-dihydroxy-, 17-acetate |
| Flugestone acetate |
| UNII-X60881643X |
| Synchronate |
| (11β)-9-Fluoro-11-hydroxy-3,20-dioxopregn-4-en-17-yl acetate |
| 17a-Acetoxy-9a-fluoro-11b-hydroxyprogesterone |
| 9-Fluoro-11b,17-dihydroxypregn-4-ene-3,20-dione-17-acetate |
| MFCD00243094 |
| Cronolone |
