CAS 36519-25-2|Neosolaniol
Introduction：Basic information about CAS 36519-25-2|Neosolaniol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Neosolaniol | ||
|---|---|---|---|
| CAS Number | 36519-25-2 | Molecular Weight | 382.405 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 515.9±50.0 °C at 760 mmHg |
| Molecular Formula | C19H26O8 | Melting Point | 171.5°C |
| MSDS | ChineseUSA | Flash Point | 180.2±23.6 °C |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate |
|---|---|
| Synonym | More Synonyms |
Neosolaniol BiologicalActivity
| Description | Neosolaniol is a type A trichothecene mycotoxin from Fusarium sp[1]. Neosolaniol evokes robust anorectic response[2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. McCormick SP, et al. Trichothecenes: from simple to complex mycotoxins. Toxins (Basel). 2011 Jul;3(7):802-14. [2]. Zhang J, et al. Comparison of Anorectic Potencies of Type A Trichothecenes T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol. Toxins (Basel). 2018 Apr 29;10(5). |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 515.9±50.0 °C at 760 mmHg |
| Melting Point | 171.5°C |
| Molecular Formula | C19H26O8 |
| Molecular Weight | 382.405 |
| Flash Point | 180.2±23.6 °C |
| Exact Mass | 382.162781 |
| PSA | 114.82000 |
| LogP | -0.07 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.578 |
| InChIKey | TVZHDVCTOCZDNE-SXDMWMEPSA-N |
| SMILES | CC(=O)OCC12CC(O)C(C)=CC1OC1C(O)C(OC(C)=O)C2(C)C12CO2 |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 4,S124,1984 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14500 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJEMAG Japanese Journal of Experimental Medicine. (Kinokuniya Book-Stores of America Co., Ltd., West Bldg., Japan Cultural and Trade Center, 1581 Webster St., San Francisco, CA 94115) V.7- 1928- Volume(issue)/page/year: 42,187,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 9700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 24870 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Behavioral - muscle weakness Behavioral - food intake (animal)
- REFERENCE :
- AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 35,636,1978
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+,Xn,F |
| Risk Phrases | 26/27/28-36-20/21/22-11 |
| Safety Phrases | 22-36/37/39-45-36/37-16-26 |
| RIDADR | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | YD0080000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
Articles16
More Articles| Toxicity induced by F. poae-contaminated feed and the protective effect of Montmorillonite supplementation in broilers. Food Chem. Toxicol. 74 , 120-30, (2014) The T-2 and HT-2 toxins, the main metabolites of Fusarium poae, induce toxicity in broilers and accumulate in tissues. Consequently, during the breeding process of broilers, diets are frequently suppl... | |
| Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS ONE 10(4) , e0124204, (2015) Shc proteins interact with the insulin receptor, indicating a role in regulating glycolysis. To investigate this idea, the activities of key glycolytic regulatory enzymes and metabolites levels were m... | |
| Hooking She3p onto She2p for myosin-mediated cytoplasmic mRNA transport. Proc. Natl. Acad. Sci. U. S. A. 112(1) , 142-7, (2015) The segregation of approximately two dozen distinct mRNAs from yeast mother to daughter cell cytoplasm is a classical paradigm for eukaryotic mRNA transport. The information for transport resides in a... |
Synonyms
| Trichothec-9-ene, 12,13-epoxy-4-β,15-diacetoxy-3-α,8-α-dihydroxy- |
| 4-β,15-Diacetoxy-3-α,8-α-dihydroxy-12,13-epoxytrichothec-9-ene |
| Trichothec-9-ene-3-α,4-β,8-α,15-tetrol, 12,13-epoxy-, 4,15-diacetate |
| (3α,4β,8α)-3,8-Dihydroxy-12,13-epoxytrichothec-9-ene-4,15-diyl diacetate |
| Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate, (3α,4β,8α)- |
| Solaniol (van) |
| 8-HYDROXYDIACETOXYSCIRPENOL |
| neosolaniol solution |
| Neosalaniol |
| NEOSOLANIOL |
