CAS 618-27-9|cis-4-hydroxy-L-proline
| Common Name | cis-4-hydroxy-L-proline | ||
|---|---|---|---|
| CAS Number | 618-27-9 | Molecular Weight | 131.130 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 355.2±42.0 °C at 760 mmHg |
| Molecular Formula | C5H9NO3 | Melting Point | 257ºC |
| MSDS | ChineseUSA | Flash Point | 168.6±27.9 °C |
Names
| Name | cis-4-hydroxy-L-proline |
|---|---|
| Synonym | More Synonyms |
cis-4-hydroxy-L-proline BiologicalActivity
| Description | cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Metabolic Disease |
| References | [1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 355.2±42.0 °C at 760 mmHg |
| Melting Point | 257ºC |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.130 |
| Flash Point | 168.6±27.9 °C |
| Exact Mass | 131.058243 |
| PSA | 69.56000 |
| LogP | -1.84 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.540 |
| InChIKey | PMMYEEVYMWASQN-IMJSIDKUSA-N |
| SMILES | O=C(O)C1CC(O)CN1 |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| D-Proline, 4-hydroxy-, (4R)- |
| (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid |
| cis-4-Hydroxy-L-proline |
| (4R)-4-Hydroxy-D-proline |
| cis-4-Hydroxyproline |
| MFCD00064319 |
| (4S)-4-Hydroxy-L-prolin |
| cis-4-Hydroxy-D-proline |
| EINECS 210-542-1 |
