Introduction：Basic information about CAS 135042-12-5|N-Boc-cis-4-Hydroxy-D-proline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | N-Boc-cis-4-Hydroxy-D-proline |
|---|
| CAS Number | 135042-12-5 | Molecular Weight | 231.246 |
|---|
| Density | 1.3±0.1 g/cm3 | Boiling Point | 390.9±42.0 °C at 760 mmHg |
|---|
| Molecular Formula | C10H17NO5 | Melting Point | 145ºC |
|---|
| MSDS | ChineseUSA | Flash Point | 190.2±27.9 °C |
|---|
| Symbol |
GHS07 | Signal Word | Warning |
|---|
Names
| Name | Boc-Cis-4-Hydroxy-D-Proline |
|---|
| Synonym | More Synonyms |
|---|
N-Boc-cis-4-Hydroxy-D-proline BiologicalActivity
| Description | N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
|---|
| Target | Non-cleavable |
|---|
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
|---|
| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
|---|
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
|---|
| Melting Point | 145ºC |
|---|
| Molecular Formula | C10H17NO5 |
|---|
| Molecular Weight | 231.246 |
|---|
| Flash Point | 190.2±27.9 °C |
|---|
| Exact Mass | 231.110672 |
|---|
| PSA | 87.07000 |
|---|
| LogP | -0.71 |
|---|
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
|---|
| Index of Refraction | 1.531 |
|---|
| InChIKey | BENKAPCDIOILGV-RNFRBKRXSA-N |
|---|
| SMILES | CC(C)(C)OC(=O)N1CC(O)CC1C(=O)O |
|---|
| Storage condition | 2-8°C |
|---|
Safety Information
| Symbol |
GHS07 |
|---|
| Signal Word | Warning |
|---|
| Hazard Statements | H319 |
|---|
| Precautionary Statements | P305 + P351 + P338 |
|---|
| Hazard Codes | Xi |
|---|
| Risk Phrases | 36 |
|---|
| Safety Phrases | 26 |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| HS Code | 2933990090 |
|---|
Customs
| HS Code | 2933990090 |
|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Synonyms
| (2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid |
| 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4S)- |
| N-Boc-cis-4-Hydroxy-D-proline |
| (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline |
| (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline |
| (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid |
| (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid |
| MFCD02094407 |
| 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4R)- |
