Introduction：Basic information about CAS 1316652-41-1|NCC-149, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NCC-149 |
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| CAS Number | 1316652-41-1 | Molecular Weight | 326.373 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C16H14N4O2S | Melting Point | 153 °C(dec.) |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide |
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| Synonym | More Synonyms |
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NCC-149 BiologicalActivity
| Description | NCC-149 is a selective HDAC8 inhibitor and can be used for neural differentiation research[1]. |
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| Related Catalog | Signaling Pathways >>Cell Cycle/DNA Damage >>HDACResearch Areas >>Neurological DiseaseSignaling Pathways >>Epigenetics >>HDAC |
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| Target | HDAC8 |
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| In Vitro | NCC-149 (5 μM, 3 days) remarkably reduces NeuN expression levels in P19 cells[1]. NCC-149 (0-40 μM, 4 days) reduces embryoid body size in a dose-dependent manner[1]. NCC-149 (5 and 20 μM, 24 h) downregulates P19 cell proliferation[1]. NCC-149 (2.5 and 5 μM, 24 h) leads to cell growth retardation by G2/M phase arrest[1]. Western Blot Analysis[1] Cell Line: P19 cells Concentration: 5 μM Incubation Time: 3 days Result: Remarkably reduced NeuN expression levels. Cell Proliferation Assay[1] Cell Line: P19 cells Concentration: 5 and 20 μM Incubation Time: 24 h Result: Downregulated cell proliferation. Cell Cycle Analysis[1] Cell Line: P19 cells Concentration: 2.5 and 5 μM Incubation Time: 24 h Result: Led to a significant increase in G2/M phase cells, with a slight decrease in S phase cells. RT-PCR[1] Cell Line: P19 cells Concentration: 25 μM or 2.5 and 5 μM Incubation Time: 4 days (25 μM) or 48 h (2.5 and 5 μM) Result: Did not reduce the HDAC8 expression at the mRNA level. Significantly and partially reduced cyclin B1 and cyclin A2 gene expression, respectively. |
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| References | [1]. Katayama S, et al. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Melting Point | 153 °C(dec.) |
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| Molecular Formula | C16H14N4O2S |
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| Molecular Weight | 326.373 |
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| Exact Mass | 326.083740 |
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| PSA | 108.83000 |
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| LogP | 1.60 |
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| Index of Refraction | 1.691 |
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| InChIKey | DORPIZJGSLWDIY-UHFFFAOYSA-N |
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| SMILES | O=C(NO)c1cccc(-c2cn(CSc3ccccc3)nn2)c1 |
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Synonyms
| N-Hydroxy-3-[1-(phenylthio)methyl-1H-1,2,3-triazol-4-yl]benzamide |
| N-oxo-3-[3-(phenylsulfanylmethyl)-1,2-dihydrotriazol-5-yl]benzamide |
| Benzamide, N-hydroxy-3-[1-[(phenylthio)methyl]-1H-1,2,3-triazol-4-yl]- |
| N-Hydroxy-3-{1-[(phenylsulfanyl)methyl]-1H-1,2,3-triazol-4-yl}benzamide |
