CAS 166388-57-4|Azido-PEG2-C2-amine
Introduction：Basic information about CAS 166388-57-4|Azido-PEG2-C2-amine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azido-PEG2-C2-amine | ||
|---|---|---|---|
| CAS Number | 166388-57-4 | Molecular Weight | 174.20100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C6H14N4O2 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | 2-[2-(2-azidoethoxy)ethoxy]ethanamine |
|---|---|
| Synonym | More Synonyms |
Azido-PEG2-C2-amine BiologicalActivity
| Description | Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
| Target | PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References | [1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. [2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1. |
Chemical & Physical Properties
| Molecular Formula | C6H14N4O2 |
|---|---|
| Molecular Weight | 174.20100 |
| Exact Mass | 174.11200 |
| PSA | 94.23000 |
| LogP | 0.44166 |
| InChIKey | ZHWGWSYNZIZTFL-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCCOCCOCCN |
| Storage condition | 2-8°C |
Synonyms
| 2-(2-(2-azidoethoxy)exthoxy)ethanamine |
| 1-AMINO-8-AZIDO-3,5-DIOXAOCTANE |
| Amino-PEG2-Azide |
| 2-azidoethyloxyethyloxyethylamine |
| 2-(2-(2-azidoethoxy)ethoxy)ethanamine |
| 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE |
| 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine |
