CAS 163706-06-7|Cangrelor
Introduction：Basic information about CAS 163706-06-7|Cangrelor, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cangrelor | ||
|---|---|---|---|
| CAS Number | 163706-06-7 | Molecular Weight | 776.35900 |
| Density | 2.087g/cm3 | Boiling Point | 979.004ºC at 760 mmHg |
| Molecular Formula | C17H25Cl2F3N5O12P3S2 | Melting Point | / |
| MSDS | / | Flash Point | 545.882ºC |
Names
| Name | [dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid |
|---|---|
| Synonym | More Synonyms |
Cangrelor BiologicalActivity
| Description | Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>P2Y ReceptorResearch Areas >>Inflammation/Immunology |
| Target | P2Y12 |
| In Vitro | Cangrelor tetrasodium has pKb of 8.6-9.2 for hP2Y12 receptor[3]. |
| In Vivo | Cangrelor tetrasodium (10 mg/kg) not only significantly decreases BLM-induced release of inflammatory cytokines (PF4, CD40 L and MPO), but also decreases the increment of platelets, neutrophils and platelet-neutrophil aggregates in the fibrotic lung and in the peripheral blood of BLM-treated mice[2]. |
| References | [1]. Bhattad VB, , et al. Intravenous cangrelor as a peri-procedural bridge with applied uses in ischemic events. Ann Transl Med. 2019;7(17):408. [2]. Zhan T, Wei T, et al. Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice. Mol Immunol. 2020;120:83-92. [3]. Bekő K, et al. Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain. J Thromb Haemost. 2017;15(6):1223-1235. |
Chemical & Physical Properties
| Density | 2.087g/cm3 |
|---|---|
| Boiling Point | 979.004ºC at 760 mmHg |
| Molecular Formula | C17H25Cl2F3N5O12P3S2 |
| Molecular Weight | 776.35900 |
| Flash Point | 545.882ºC |
| Exact Mass | 774.94800 |
| PSA | 335.94000 |
| LogP | 2.92350 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.722 |
| InChIKey | PAEBIVWUMLRPSK-IDTAVKCVSA-N |
| SMILES | CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2C1OC(COP(=O)(O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O)C(O)C1O |
Synonyms
| UNII-6AQ1Y404U7 |
| Cangrelor |
| AR-C69931 |
