Introduction：Basic information about CAS 316-81-4|Thioproperazine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thioproperazine |
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| CAS Number | 316-81-4 | Molecular Weight | 446.62900 |
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| Density | 1.237g/cm3 | Boiling Point | 612.2ºC at 760mmHg |
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| Molecular Formula | C22H30N4O2S2 | Melting Point | 140ºC |
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| MSDS | / | Flash Point | 324ºC |
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Names
| Name | thioproperazine |
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| Synonym | More Synonyms |
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Thioproperazine BiologicalActivity
| Description | Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease |
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| In Vivo | Thioproperazine (5 mg/kg; i.p.; single) increases accumulation of dopamine in rat striatum[1]. Animal Model: Male charles river rats (200-250 g)[1]. Dosage: 5 mg/kg Administration: Intraperitoneal injection; single. Result: Markedly decreased dopamine levels (26%), and accelerated synthesis and utilization of dopamine in the striatum (dopamine specific activity was enhanced 250%). |
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Chemical & Physical Properties
| Density | 1.237g/cm3 |
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| Boiling Point | 612.2ºC at 760mmHg |
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| Melting Point | 140ºC |
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| Molecular Formula | C22H30N4O2S2 |
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| Molecular Weight | 446.62900 |
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| Flash Point | 324ºC |
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| Exact Mass | 446.18100 |
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| PSA | 80.78000 |
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| LogP | 4.19870 |
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| Index of Refraction | 1.615 |
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| InChIKey | VZYCZNZBPPHOFY-UHFFFAOYSA-N |
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| SMILES | CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SP5400000
- CHEMICAL NAME :
- Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)-
- CAS REGISTRY NUMBER :
- 316-81-4
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C22-H30-N4-O2-S2
- MOLECULAR WEIGHT :
- 446.68
- WISWESSER LINE NOTATION :
- T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 830 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 130 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 1-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 5 mg/kg
- REFERENCE :
- CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975
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Safety Information
Customs
| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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Synonyms
| 2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin |
| 10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide |
| Majeptyl |
| Megeptil |
| Thioproperazine |
| Sulfenazin |
| N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide |
| 10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid |
| Cephalmin |
| Thioperazine |
| Mazeptyl |
| Thioproperazin |
| thiproperazine |
| Vontil |
| Tioproferazina |
