Introduction：Basic information about CAS 39800-28-7|2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-o, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2H-1,3,2-Oxazaphosphorin-2-amine,N,3-bis(2-chloroethyl)tetrahydro-4-hydroperoxy-, 2-oxide |
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| CAS Number | 39800-28-7 | Molecular Weight | 293.08 |
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| Density | 1.46g/cm3 | Boiling Point | 419.9ºC at 760mmHg |
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| Molecular Formula | C7H15Cl2N2O4P | Melting Point | / |
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| MSDS | / | Flash Point | 207.8ºC |
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Names
| Name | 4-hydroperoxyifosfamide |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | 4-Hydroperoxyifosfamide is an anticancer agent that can penetrate the blood-brain barrier (BBB)[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| References | [1]. Ishimoto TM, et al. Allelic variants of the human glutathione S-transferase P1 gene confer differential cytoprotection against anticancer agents in Escherichia coli. Pharmacogenetics. 2002 Oct;12(7):543-53. |
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Chemical & Physical Properties
| Density | 1.46g/cm3 |
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| Boiling Point | 419.9ºC at 760mmHg |
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| Molecular Formula | C7H15Cl2N2O4P |
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| Molecular Weight | 293.08 |
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| Flash Point | 207.8ºC |
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| Exact Mass | 292.01500 |
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| PSA | 80.84000 |
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| LogP | 2.02850 |
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| Index of Refraction | 1.525 |
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| InChIKey | YGZIWEZFFBPCLN-UHFFFAOYSA-N |
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| SMILES | O=P1(NCCCl)OCCC(OO)N1CCCl |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- MX2435000
- CHEMICAL NAME :
- Hydroperoxide, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro- 2H-1,3,2-oxazaphospho rin- 4-yl-, P-oxide
- CAS REGISTRY NUMBER :
- 39800-28-7
- LAST UPDATED :
- 199310
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C7-H15-Cl2-N2-O4-P
- MOLECULAR WEIGHT :
- 293.11
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 180 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 220 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 60,361,1976
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Synonyms
| Hydroperoxyisophosphamide |
| 4-Hydroperoxyisophosphamid |
| 4-Hydroperoxyifosfamid |
| asta6760 |
| 4-hydroperoxyisophosphamide |
