CAS 138-56-7|Trimethobenzamide

Introduction：Basic information about CAS 138-56-7|Trimethobenzamide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameTrimethobenzamide
CAS Number138-56-7Molecular Weight388.45700
Density1.131 g/cm3Boiling Point506.9ºC at 760 mmHg
Molecular FormulaC21H28N2O5Melting Point/
MSDS/Flash Point260.4ºC

Names

NameN-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
SynonymMore Synonyms

Trimethobenzamide BiologicalActivity

DescriptionTrimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].
Related CatalogSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine ReceptorResearch Areas >>Neurological Disease
Target

D2 receptor[1]

In VitroTrimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].
In VivoThe oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].
References

[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

Chemical & Physical Properties

Density1.131 g/cm3
Boiling Point506.9ºC at 760 mmHg
Molecular FormulaC21H28N2O5
Molecular Weight388.45700
Flash Point260.4ºC
Exact Mass388.20000
PSA69.26000
LogP2.97370
Vapour Pressure2.13E-10mmHg at 25°C
InChIKeyFEZBIKUBAYAZIU-UHFFFAOYSA-N
SMILESCOc1cc(C(=O)NCc2ccc(OCCN(C)C)cc2)cc(OC)c1OC

Safety Information

Hazard CodesXi
HS Code2924299090

Customs

HS Code2924299090
Summary2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Synonyms

Tebamide
Trimethobenzamid
EINECS 205-332-1
Trimethobenzamidum
Trimazide
Benzacot
trimethobenzamide
Tribenzagan
Tigan
Stemetic
Trimetobenzamida
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