CAS 1354744-91-4|Naloxegol oxalate

Introduction：Basic information about CAS 1354744-91-4|Naloxegol oxalate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Naloxegol oxalate BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Naloxegol oxalate
CAS Number	1354744-91-4	Molecular Weight	741.820
Density	/	Boiling Point	/
Molecular Formula	C₃₆H₅₅NO₁₅	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(4R,4aS,7S,7aR,12bS)-7-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-prop-2-enyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol,oxalic acid
Synonym	More Synonyms

Naloxegol oxalate BiologicalActivity

Description	Naloxegol oxalate (NKTR-118 oxalate; AZ-13337019 oxalate) is an opioid-receptor antagonist[1].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological Disease
Target	Opioid receptor[1]
References	[1]. Garnock-Jones KP, et al. Naloxegol: a review of its use in patients with opioid-induced constipation. Drugs. 2015 Mar;75(4):419-25. [2]. Yoon SC, et al. Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem. Patient Prefer Adherence. 2017 Jul 24;11:1265-1271.

Chemical & Physical Properties

Molecular Formula	C₃₆H₅₅NO₁₅
Molecular Weight	741.820
Exact Mass	741.357178
PSA	201.37000
LogP	0.95700
InChIKey	MNYIRXLCPODKLG-VUTNLTPYSA-N
SMILES	C=CCN1CCC23c4c5ccc(O)c4OC2C(OCCOCCOCCOCCOCCOCCOCCOC)CCC3(O)C1C5.O=C(O)C(=O)O
Storage condition	2-8℃

Synonyms

NKTR-118 oxalate

Naloxegol oxalate (USAN)

Morphinan-3,14-diol, 4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-, (5α,6α)-, ethanedioate (1:1) (salt)

Naloxegol oxalate

(5α,6α)-17-Allyl-6-(2,5,8,11,14,17,20-heptaoxadocosan-22-yloxy)-4,5-epoxymorphinan-3,14-diol ethanedioate (1:1)

UNII-65I14TNM33

4,5α-epoxy-6α-[(3,6,7,12,15,18,21-heptaoxadocosyl)oxy]-17-(prop-2-enyl)morphinan-3,14-diol hydrogen ethanedioate

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