CAS 612-82-8|4,4'-Bi-o-toluidine dihydrochloride

Introduction：Basic information about CAS 612-82-8|4,4'-Bi-o-toluidine dihydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chemical & Physical Properties
3. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
4. Safety Information
5. Articles25
6. Synonyms

Common Name	4,4'-Bi-o-toluidine dihydrochloride
CAS Number	612-82-8	Molecular Weight	285.212
Density	/	Boiling Point	361ºC at 760 mmHg
Molecular Formula	C₁₄H₁₈Cl₂N₂	Melting Point	>300°C
MSDS	ChineseUSA	Flash Point	/
Symbol	GHS07, GHS08, GHS09	Signal Word	Danger

Names

Name	3,3'-Dimethylbenzidine dihydrochloride
Synonym	More Synonyms

Chemical & Physical Properties

Boiling Point	361ºC at 760 mmHg
Melting Point	>300°C
Molecular Formula	C₁₄H₁₈Cl₂N₂
Molecular Weight	285.212
Exact Mass	284.084717
PSA	52.04000
LogP	5.90120
InChIKey	LUKPNZHXJRJBAN-UHFFFAOYSA-N
SMILES	Cc1cc(-c2ccc(N)c(C)c2)ccc1N.Cl.Cl

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD1226000

CHEMICAL NAME :: Benzidine, 3,3'-dimethyl-, dihydrochloride

CAS REGISTRY NUMBER :: 612-82-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C14-H16-N2.2Cl-H

MOLECULAR WEIGHT :: 285.24

WISWESSER LINE NOTATION :: ZR B1 DR DZ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1120 mg/kg/14D-C

TOXIC EFFECTS :: Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 18200 mg/kg/13W-C

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1820 mg/kg/65W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15288 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-390,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1372 No. of Facilities: 132 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1178 (estimated) No. of Female Employees: 105 (estimated)

Safety Information

Symbol	GHS07, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H302-H350-H411
Precautionary Statements	P201-P273-P301 + P312 + P330-P308 + P313-P391-P501
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R22;R45;R51/53;R68
Safety Phrases	S53-S45-S61
RIDADR	UN 3077 9/PG 3
WGK Germany	3
RTECS	DD1226000
Packaging Group	III
Hazard Class	6.1(b)

Articles25

Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

Environ. Mol. Mutagen. 48(5) , 404-13, (2007)

4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.

Mutat. Res. 319(1) , 19-30, (1993)

Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobe...

Iron(III) oxidized nucleophilic coupling of catechol with o-tolidine/p-toluidine followed by 1,10-phenanthroline as new and sensitivity improved spectrophotometric methods for iron present in chemicals, pharmaceutical, edible green leaves, nuts and lake water samples.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 86 , 152-8, (2012)

A nucleophile formed from iron(III) oxidized catechol in 0.1M hydrochloric acid couple with o-tolidine, system 1/p-toluidine, system 2 to produce dye product, λ max 520 nm. The system 1/2 obeys Beer's...

Synonyms

(1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride

O-TOLIDINE HYDROCHLORIDE

3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine dihydrochloride

8-Piperazin-1-yl-quinoline

MFCD00012960

3,3'-Dimethyl-4,4'-biphenyldiamine dihydrochloride

3,3'-Dimethyl-benzidin,Dihydrochlorid

o-Tolidine dihydroch

3,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride

Benzidine, 3,3'-dimethyl-, dihydrochloride

[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride

3,3′-Dimethylbenzidine dihydrochloride

3,3'-dimethyl-benzidine,dihydrochloride

3,3'-dimethylbenzidine diammonium chloride

O-TolidineHydrochlorideGr

EINECS 210-322-5

o-Tolidine2HCl

THALLIUM ARSENATE

O-TOLIDINE DI HCL

4,4'-Bi-o-toluidine dihydrochloride

[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, hydrochloride (1:2)

3,3'-Dimethylbenzidine dihydrochloride

4,4′-Diamino-3,3′-dimethylbiphenyl dihydrochloride

3,3'-Dimethyl-4,4'-diaminobiphenyl dihydrochloride

O-TOLIDINE DIHYDROCHLORIDE

ZR B1 DR DZ C1 &&2HCl

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