Introduction：Basic information about CAS 16052-06-5|HEPPS, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | HEPPS |
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| CAS Number | 16052-06-5 | Molecular Weight | 252.331 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H20N2O4S | Melting Point | 237-239 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | / |
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Names
| Name | hepps |
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| Synonym | More Synonyms |
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HEPPS BiologicalActivity
| Description | HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier[1]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| References | [1]. Kim HY, et al. EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat Commun. 2015 Dec 8;6:8997. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Melting Point | 237-239 °C(lit.) |
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| Molecular Formula | C9H20N2O4S |
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| Molecular Weight | 252.331 |
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| Exact Mass | 252.114380 |
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| PSA | 89.46000 |
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| LogP | -2.46 |
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| Index of Refraction | 1.537 |
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| InChIKey | OWXMKDGYPWMGEB-UHFFFAOYSA-N |
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| SMILES | O=S(=O)(O)CCCN1CCN(CCO)CC1 |
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| Storage condition | Store at RT. |
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| Water Solubility | H2O: 1 M at 20 °C, clear, colorless |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TM2649130
- CHEMICAL NAME :
- 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)-
- CAS REGISTRY NUMBER :
- 16052-06-5
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C9-H20-N2-O4-S
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- >316 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | TM2649130 |
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| HS Code | 29335995 |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles6
More Articles
| Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations. J. Pharmacol. Toxicol. Methods 70(2) , 188-94, (2014) Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-mala... | |
| Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation. J. Biol. Chem. 290 , 21615-28, (2015) Heat shock protein 90 (hsp90) drives heme insertion into the β1 subunit of soluble guanylate cyclase (sGC) β1, which enables it to associate with a partner sGCα1 subunit and mature into a nitric oxide... | |
| EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques. Nat. Commun. 6 , 8997, (2015) Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical sympto... | |
Synonyms
| HEPPS |
| 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic Acid |
| EINECS 240-198-8 |
| MFCD00006160 |
| 3-[4-(2-Hydroxyethyl)-1-piperazinyl]-1-propanesulfonic acid |
| 3-(4-(2-Hydroxyethyl)piperazin-1-yl)propane-1-sulfonic acid |
| 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic Acid [Good's buffer component |
| 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- |
| 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid |
| EPPS |
| 4-Hydroxyerhylpiperazine-1-propanesulfonic acid |
