CAS 138559-60-1|Antileukinate

Introduction：Basic information about CAS 138559-60-1|Antileukinate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Antileukinate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Antileukinate
CAS Number	138559-60-1	Molecular Weight	1003.19000
Density	/	Boiling Point	/
Molecular Formula	C₄₅H₆₆N₁₈O₇S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	IL-8 Inhibitor
Synonym	More Synonyms

Antileukinate BiologicalActivity

Description	Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR). Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>CXCRResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>CXCR
In Vitro	Antileukinate inhibits the binding of human eotaxin to human eosinophils with an IC50 of 8.2 μM[2]. Antileukinate (10 μM, 100 μM) significantly suppresses eosinophil chemotaxis to human eotaxin[2].
In Vivo	Antileukinate (52.63 mg/kg; s.c.) protectes mice against acute pancreatitis and associated lung injury[1]. Antileukinate (5mg/kg; s.c.) inhibits the interaction between murine eotaxin and murine eosinophil[2]. Animal Model: Swiss mice(20-25g)[1] Dosage: 52.63 mg/kg Administration: Subcutaneous injection Result: Reduced pancreatic edema induced by Caerulein (50 μg/kg).
References	[1]. Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138(1):40-8. [2]. Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22(5):116-25.

Chemical & Physical Properties

Molecular Formula	C₄₅H₆₆N₁₈O₇S
Molecular Weight	1003.19000
Exact Mass	1002.51000
PSA	473.77000
LogP	4.18650
InChIKey	FVRBFNYUBYTVIQ-NGTAMTFRSA-N
SMILES	CC(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CS)C(=O)NC(CCCN=C(N)N)C(N)=O

Safety Information

Hazard Codes	Xi

Synonyms

ac-rrwwcr-nh2

ac-arg-arg-trp-trp-cys-arg-nh2

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