CAS 138-60-3|chelidamic acid
| Common Name | chelidamic acid | ||
|---|---|---|---|
| CAS Number | 138-60-3 | Molecular Weight | 183.118 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 428.3±45.0 °C at 760 mmHg |
| Molecular Formula | C7H5NO5 | Melting Point | 267 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 212.8±28.7 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Chelidamic acid |
|---|---|
| Synonym | More Synonyms |
chelidamic acid BiologicalActivity
| Description | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Others |
| Target | Ki: 33 μM (Glutamate decarboxylase)[3]. |
| In Vitro | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton[1]. Chelidamic acid has good coordination ability with noble metal ions[2]. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM[3]. |
| References | [1]. Searcey M, et al. Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8):837-55. [2]. Espinet P, et al. Mesogenic palladium complexes with pincer ligands derived from dipicolinic acid. Inorg Chem. 2000 Aug, 7;39(16):3645-51. [3]. Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34(23):4145-50. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 428.3±45.0 °C at 760 mmHg |
| Melting Point | 267 °C (dec.)(lit.) |
| Molecular Formula | C7H5NO5 |
| Molecular Weight | 183.118 |
| Flash Point | 212.8±28.7 °C |
| Exact Mass | 183.016769 |
| PSA | 107.46000 |
| LogP | -1.43 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.635 |
| InChIKey | XTLJJHGQACAZMS-UHFFFAOYSA-N |
| SMILES | O=C(O)c1cc(=O)cc(C(=O)O)[nH]1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles8
More Articles| Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem. Pharmacol. 34 , 4145-4150, (1985) Twenty conformationally restricted analogues of glutamate including benzoic acids, hydroxy-benzoic acids, pyridine dicarboxylic acids, and pyran dicarboxylic acids were tested as inhibitors of glutama... | |
| Synthesis, DNA-cleaving properties and cytotoxicity of intercalating chelidamic acid derivatives. Anticancer Drug Des. 13(8) , 837-55, (1998) We have explored the potential antitumour activity of DNA-intercalating free radical generators based on compounds constructed from 9-anilinoacridine and chelidamic acid as an iron (II) binding centre... | |
| [Use of the radial hemolysis reaction for titrating antirabies sera]. Vopr. Virusol. 29(3) , 360-1, (1984) |
Synonyms
| Pd(OH)2/C |
| chelidamic acid |
| 4-Hydroxypyridine-2,6-dicarboxylic Acid Monohydrate |
| 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid |
| MFCD00066478 |
| 4-Hydroxy-2,6-pyridinedicarboxylic acid |
| 4-oxo-1,4-dihydropyridine-2,6-dicarboxylic acid |
| 4-PYRIDONE-2,6-DICARBOXYLIC ACID |
| 1,4-dihydro-4-oxo-2,6-pyridinedicarboxylic acid |
| .HELIDAMIC AICD |
| 2,6-Pyridinedicarboxylic acid, 1,4-dihydro-4-oxo- |
| CHELIDAMIC ACID HYDRATE |
| Chelidamaic acid |
| Chelidamic Acid Monohydrate |
| Chelidamic aicd |
| 2,6-Pyridinedicarboxylic acid, 4-hydroxy- |
| Ammox-chelidonic acid |
| 4-Hydroxypyridine-2,6-dicarboxylic acid |
| chelidamic acid approx. |
| EINECS 205-335-8 |
| 4-hydroxyl-pyridine-2,6-dicarboxylic acid |
