CAS 4419-39-0|Beclometasone
Introduction：Basic information about CAS 4419-39-0|Beclometasone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Beclometasone | ||
|---|---|---|---|
| CAS Number | 4419-39-0 | Molecular Weight | 521.042 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 630.5±55.0 °C at 760 mmHg |
| Molecular Formula | C22H29ClO5 | Melting Point | 210ºC |
| MSDS | ChineseUSA | Flash Point | 335.1±31.5 °C |
Names
| Name | beclomethasone |
|---|---|
| Synonym | More Synonyms |
Beclometasone BiologicalActivity
| Description | Beclometasone (Beclomethasone) is a prototype glucocorticoid receptor agonist. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Glucocorticoid ReceptorResearch Areas >>Inflammation/Immunology |
| Target | Glucocorticoid Receptor[1] |
| In Vitro | An inhibition of the normal physiological neutrophil migration and of neutrophil chemotaxis directed by wounding-induced inflammation is detected at 4 h after administration of 25 μM Beclomethasone. Tumour cell invasion and micrometastasis is also reduced in embryos incubated in 25 μM Beclomethasone 4 h before implantation. In addition, the lysyl oxidase inhibitor β-aminoproprionitrile (βAPN) largely reduces fibrillar collagen and enhances the CHT-TF transmigration of neutrophils, leading to a significant increase of tumour cell invasion and subsequent formation of micrometastases. Notably, βAPN inhibits neutrophil chemotaxis induced by inflammation, indicating that the increase of tumour cell invasion in βAPN-treated embryos is correlated with enhanced non-pathological neutrophil migration, but not with inflammation[1]. |
| Cell Assay | The transgenic lines Tg(fli1:GFP) and Tg(mpx:GFP) are used in this study. 0.2 mM N-phenylthiourea (PTU) is applied to prevent pigment formation from 1 day post-fertilization (dpf). For Pu.1 knockdown, Pu.1 MO (1 mM for partial knockdown and 2 mM for complete knockdown is injected into the yolk at the one-cell stage. For pharmacological inhibition, the VEGFR tyrosine kinase inhibitors KRN633 (0.1-1 μM) or Sunitinib (0.1-1 μM), Beclomethasone (25 μM) and β-amino-proprionitrile (βAPN, 500 μM) are applied directly to the egg water and refreshed every 2 days. For pharmacological inhibition, Beclomethasone is applied to the embryos 4 h before implantation and KRN633, Sunitinib and βAPN are applied 4-6 h post-implantation. For each cell line or condition, data are representative of ≥ three independent experiments, with ≥30 embryos/group. Experiments are discarded when the survival rate of the control group is <90%[1]. |
| References | [1]. He S, et al. Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. J Pathol. 2012 Aug;227(4):431-45. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 630.5±55.0 °C at 760 mmHg |
| Melting Point | 210ºC |
| Molecular Formula | C22H29ClO5 |
| Molecular Weight | 521.042 |
| Flash Point | 335.1±31.5 °C |
| Exact Mass | 520.222778 |
| PSA | 94.83000 |
| LogP | 4.59 |
| Vapour Pressure | 0.0±4.2 mmHg at 25°C |
| Index of Refraction | 1.564 |
| InChIKey | NBMKJKDGKREAPL-DVTGEIKXSA-N |
| SMILES | CC1CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC2(C)C1(O)C(=O)CO |
| Storage condition | 2-8°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles56
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| In vitro evaluation of nonconventional accessory devices for pressurized metered-dose inhalers. Ann. Allergy Asthma Immunol. 113(1) , 55-62, (2014) The selection of accessory devices for pressurized metered-dose inhalers (pMDIs) by health care professionals is typically cost driven without consideration of how the device modifies clinical outcome... | |
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Synonyms
| Beclometasone |
| (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Beclomethasone |
| EINECS 224-585-9 |
| MFCD00135614 |
| Pregna-1,4-diene-3,20-dione, 9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)- |
| beclometasone 17,21-dipropionate |
| 9-Chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate |
