CAS 82752-99-6|Nefazodone hydrochloride
| Common Name | Nefazodone hydrochloride | ||
|---|---|---|---|
| CAS Number | 82752-99-6 | Molecular Weight | 506.46800 |
| Density | / | Boiling Point | 599.6ºC at 760 mmHg |
| Molecular Formula | C25H33Cl2N5O2 | Melting Point | 186-188ºC |
| MSDS | ChineseUSA | Flash Point | 316.4ºC |
Names
| Name | nefazodone hydrochloride |
|---|---|
| Synonym | More Synonyms |
Nefazodone hydrochloride BiologicalActivity
| Description | Nefazodone hydrochloride is an antidepressant drug. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Neurological Disease |
| References | [1]. Bengi Uslu, et al. Electrochemical characterisation of nefazodone hydrochloride and voltammetric determination of the drug in pharmaceuticals and human serum. Analytica Chimica Acta Volume 462, Issue 1, 26 June 2002, Pages 49–57 [2]. SHEN Wei-Yang, et al. Determination of Nefazodone Hydrochloride Tablets by HPLC. Chinese Journal of Pharmaceuticals, 2003-10 |
Chemical & Physical Properties
| Boiling Point | 599.6ºC at 760 mmHg |
|---|---|
| Melting Point | 186-188ºC |
| Molecular Formula | C25H33Cl2N5O2 |
| Molecular Weight | 506.46800 |
| Flash Point | 316.4ºC |
| Exact Mass | 505.20100 |
| PSA | 55.53000 |
| LogP | 4.35680 |
| InChIKey | DYCKFEBIOUQECE-UHFFFAOYSA-N |
| SMILES | CCc1nn(CCCN2CCN(c3cccc(Cl)c3)CC2)c(=O)n1CCOc1ccccc1.Cl |
| Storage condition | Desiccate at RT |
| Water Solubility | DMSO: ~11 mg/mL at 60 °C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles30
More Articles| Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity. J. Chromatogr. A. 1374 , 122-33, (2014) The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab... | |
| The relation between changes in patients' interpersonal impact messages and outcome in treatment for chronic depression. J. Consult. Clin. Psychol. 80(3) , 354-64, (2012) Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain ... | |
| Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug. Drug Metab. Dispos. 36(6) , 1016-29, (2008) In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attem... |
Synonyms
| MFCD00865396 |
| 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one,hydrochloride |
| Nefazodone Hydrochloride |
