Introduction：Basic information about CAS 13395-02-3|Aristololactam I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aristololactam I |
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| CAS Number | 13395-02-3 | Molecular Weight | 293.273 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 463.9±34.0 °C at 760 mmHg |
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| Molecular Formula | C17H11NO4 | Melting Point | 319 °C |
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| MSDS | / | Flash Point | 234.4±25.7 °C |
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Names
| Name | Aristolactam I |
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| Synonym | More Synonyms |
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Aristololactam I BiologicalActivity
| Description | Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage.Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>CaspaseResearch Areas >>Inflammation/Immunology |
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| References | [1]. Li J, et al. Toxicities of aristolochic acid I and aristololactam I in cultured renal epithelial cells. Toxicol In Vitro. 2010 Jun;24(4):1092-7. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 463.9±34.0 °C at 760 mmHg |
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| Melting Point | 319 °C |
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| Molecular Formula | C17H11NO4 |
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| Molecular Weight | 293.273 |
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| Flash Point | 234.4±25.7 °C |
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| Exact Mass | 293.068817 |
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| PSA | 60.55000 |
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| LogP | 2.97 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.763 |
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| InChIKey | MXOKGWUJNGEKBH-UHFFFAOYSA-N |
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| SMILES | COc1cccc2c1cc1c3c(cc4c(c32)OCO4)C(=O)N1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DE5375000
- CHEMICAL NAME :
- Benzo(f)-1,3-benzodioxolo(6,5,4-cd)indol-5(6H)-one, 8-methoxy-
- CAS REGISTRY NUMBER :
- 13395-02-3
- BEILSTEIN REFERENCE NO. :
- 0307971
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C17-H11-N-O4
- MOLECULAR WEIGHT :
- 293.29
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 50 ug/plate
- REFERENCE :
- CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 7,59,1986
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | UN 2811 |
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| Packaging Group | III |
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| Hazard Class | 6.1(b) |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1,3-Benzodioxolo[6,5,4-cd]benz[f]indol-5(6H)-one, 8-methoxy- |
| Aristololactam |
| 8-Methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one |
