Introduction：Basic information about CAS 36505-84-7|Buspirone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Buspirone |
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| CAS Number | 36505-84-7 | Molecular Weight | 385.50300 |
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| Density | 1.24g/cm3 | Boiling Point | 613.9ºC at 760 mmHg |
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| Molecular Formula | C21H31N5O2 | Melting Point | 41678ºC |
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| MSDS | / | Flash Point | 325.1ºC |
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Names
| Name | buspirone |
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| Synonym | More Synonyms |
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Buspirone BiologicalActivity
| Description | Buspirone is an orally active 5-HT1A receptor agonist. Buspirone is a potent anticancer agent. Buspirone shows antiproliferative activity. Buspirone can be used for anxiety, depression and cancer research[1][2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
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| In Vitro | Buspirone (0-400 µg/mL; 6 hours) has cytotoxic effect in Lymphocytes[1].Buspirone (0-180 µg/mL; 0-3 hours; Lymphocytes)induces ROS formation, mitochondrial membrane potential collapse(MMP), lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG)[1]. Cell Viability Assay[1] Cell Line: Lymphocytes Concentration: 0, 4, 20, 40, 200 and 400 µg/mL Incubation Time: 6 hours Result: Decreased cell viability in a dose-dependent manner. |
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| In Vivo | Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) reduces anxiety/depression behaviors[2]. Buspirone (1-5 mg/kg; i.p. and i.g.; for 5 days; C57BL/6N mice) restores IS-shifted β-diversity in the gut microbiota[2]. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced TNF-α expression and NF-κB+/Iba1+ cell population in the hippocampus and myeloperoxidase activity and NF-κB+/CD11c+ cell population in the colon. Animal Model: Male C57BL/6N mice[2] Dosage: 1 and 5 mg/kg Administration: Oral gavage and intraperitoneal injection; for 5 days Result: Reduced the IS- or EC-induced gut Proteobacteria population. |
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| References | [1]. Salimi A, et, al. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Curr Clin Pharmacol. 2018;13(2):120-127. [2]. Kim JK, et, al. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Sci Rep. 2021 Mar 17;11(1):6094. |
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Chemical & Physical Properties
| Density | 1.24g/cm3 |
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| Boiling Point | 613.9ºC at 760 mmHg |
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| Melting Point | 41678ºC |
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| Molecular Formula | C21H31N5O2 |
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| Molecular Weight | 385.50300 |
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| Flash Point | 325.1ºC |
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| Exact Mass | 385.24800 |
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| PSA | 69.64000 |
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| LogP | 2.02900 |
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| InChIKey | QWCRAEMEVRGPNT-UHFFFAOYSA-N |
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| SMILES | O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(c2ncccn2)CC1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CL9910000
- CHEMICAL NAME :
- 8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
- CAS REGISTRY NUMBER :
- 36505-84-7
- BEILSTEIN REFERENCE NO. :
- 0964904
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H31-N5-O2
- MOLECULAR WEIGHT :
- 385.57
- WISWESSER LINE NOTATION :
- T6VNV EXTJ B4- AT6N DNTJ D- BT6N CNJ&& E-& AL5XTJ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 399 mg/kg/19D-I
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 1,409,1976
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Safety Information
| Hazard Codes | T: Toxic; |
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| Risk Phrases | R25 |
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| Safety Phrases | S45 |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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| RTECS | CL9915000 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Ansial |
| 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro(4.5)-decane-7,9-dione |
| EINECS 253-072-2 |
| Anxiron |
| 8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione |
| MFCD00078569 |
| Buspironum [INN-Latin] |
| Buspironum |
| Ansiced |
| Bespar |
| Buspirona [INN-Spanish] |
| [14C]-Buspirone |
| 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione |
| Buspirona |
