CAS 132539-06-1|Olanzapine
| Common Name | Olanzapine | ||
|---|---|---|---|
| CAS Number | 132539-06-1 | Molecular Weight | 312.432 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 476.0±55.0 °C at 760 mmHg |
| Molecular Formula | C17H20N4S | Melting Point | 195°C |
| MSDS | USA | Flash Point | 241.7±31.5 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | olanzapine |
|---|---|
| Synonym | More Synonyms |
Olanzapine BiologicalActivity
| Description | Olanzapine(LY170053) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist.IC50 Value:Target: 5-HT ReceptorOlanzapine is a thienobenzodiazepine that blocks especially the serontonin (5-hydroxytryptamine [5-HT]) 5-HT2A and the dopamine D2 receptors (Ki values are 4 and 11 nM respectively) as well as muscarinic (M1), histamine (H1), 5-HT2C, 5-HT3 to 5-HT6, adrenergic (α(l)), and D4 receptors. Atypical antipsychotic for the treatment of schizophrenia. Olanzapine displays anticholinergic properties. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Autophagy >>MitophagyResearch Areas >>Neurological Disease |
| References | [1]. Cipriani A, Rendell JM, Geddes J. Olanzapine in long-term treatment for bipolar disorder. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004367. doi: 10.1002/14651858. [2]. Meera Narasimhan, Travis O Bruce, and Prakash Masand. Review of olanzapine in the management of bipolar disorders. Neuropsychiatr Dis Treat. 2007 October; 3(5): 579-587. [3]. Vieta E. Olanzapine in bipolar disorder. Expert Opin Pharmacother. 2004 Jul;5(7):1613-9. [4]. Bymaster FP, Calligaro DO, Falcone JF et al. Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology. 1996 Feb;14(2):87-96. [5]. Moore NA, Tye NC, Axton MS, Risius FC. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent. J Pharmacol Exp Ther. 1992 Aug;262(2):545-51. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 476.0±55.0 °C at 760 mmHg |
| Melting Point | 195°C |
| Molecular Formula | C17H20N4S |
| Molecular Weight | 312.432 |
| Flash Point | 241.7±31.5 °C |
| Exact Mass | 312.140869 |
| PSA | 59.11000 |
| LogP | 2.18 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.709 |
| InChIKey | KVWDHTXUZHCGIO-UHFFFAOYSA-N |
| SMILES | Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1 |
| Storage condition | -20°C Freezer |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi,Xn,F |
| Risk Phrases | 36/38-36-20/21/22-11 |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles112
More Articles| The stress stability of olanzapine: studies of interactions with excipients in solid state pharmaceutical formulations. Drug Dev. Ind. Pharm. 41(3) , 502-14, (2015) Stress stability testing represents an important part of the drug development process. It is used as an important tool for the identification of degradation products and degradation pathways, as well ... | |
| Simple and sensitive screening and quantitative determination of 88 psychoactive drugs and their metabolites in blood through LC–MS/MS: Application on postmortem samples J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 970 , 1-7, (2014) • The introduction has been modified. • More references have been added to the text. • Limitations of the method have been discussed more in detail. | |
| Olanzapine inhibits the proliferation and induces the differentiation of glioma stem-like cells through modulating the Wnt signaling pathway in vitro. Eur. Rev. Med. Pharmacol. Sci. 19 , 2406-15, (2015) Olanzapine, a D2/5-HT2 antagonist, is often used as an atypical antipsychotic drug in clinical. Previous research has found its new pharmacological influence on enhancing the differentiation of neural... |
Synonyms
| 10H-thieno2,3-b1,5benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- |
| Olanzapine |
| 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine |
| 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine |
| 2-méthyl-4-(4-méthylpipérazin-1-yl)-10H-thiéno[2,3-b][1,5]benzodiazépine |
| 2-Methyl-4-(4-methyl-1-piperazinyl)- 10H-thieno[2,3-b][1,5]benzodiazepine LY-170053 |
| Integrol |
| Oltal |
| Larmac |
| ZYPREXA |
| OLANZAPINE FORM I |
| 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine |
| 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno2,3-b1,5benzodiazepine |
| lanzac |
| Oleanz |
| 10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)- |
| 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepin |
| Oliza |
| MFCD00866702 |
| EINECS 200-835-2 |
