Introduction：Basic information about CAS 164365-88-2|Boc-NH-C4-Br, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boc-NH-C4-Br |
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| CAS Number | 164365-88-2 | Molecular Weight | 252.149 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 308.8±25.0 °C at 760 mmHg |
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| Molecular Formula | C9H18BrNO2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 140.5±23.2 °C |
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| Symbol |
GHS05 | Signal Word | Danger |
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Names
| Name | tert-butyl N-(4-bromobutyl)carbamate |
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| Synonym | More Synonyms |
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Boc-NH-C4-Br BiologicalActivity
| Description | Boc-NH-C4-Br is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. Hu R, et, al. Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor. Eur J Med Chem. 2022 Jan 5;227:113922. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 308.8±25.0 °C at 760 mmHg |
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| Molecular Formula | C9H18BrNO2 |
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| Molecular Weight | 252.149 |
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| Flash Point | 140.5±23.2 °C |
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| Exact Mass | 251.052078 |
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| PSA | 38.33000 |
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| LogP | 2.78 |
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| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
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| Index of Refraction | 1.473 |
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| InChIKey | GKGFAEREWWZBKY-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)OC(=O)NCCCCBr |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS05 |
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| Signal Word | Danger |
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| Hazard Statements | H318 |
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| Precautionary Statements | P280-P305 + P351 + P338 |
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| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R41 |
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| Safety Phrases | S26-S39 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2924199090 |
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Customs
| HS Code | 2924199090 |
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| Summary | 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Articles2
More Articles
| H. Ina et al. J. Org. Chem. 61 , 1023 , (1995)
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| D.L. Selwood et al. J. Med. Chem. 4 , 78, (2001)
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Synonyms
| 4-bromobutylamine tert-butylcarbamate |
| N-Boc 4-bromobutan-1-amine |
| tert-butyl 4-bromobutylcarbamate |
| Carbamic acid, N-(4-bromobutyl)-, 1,1-dimethylethyl ester |
| BrCH2CH2CH2CH2NHBoc |
| 2-Methyl-2-propanyl (4-bromobutyl)carbamate |
| MFCD06201020 |
| N-(4-Bromobutyl)-Carbamic Acid 1,1-Dimethylethyl Ester |
| tert-Butyl (4-bromobutyl)carbamate |
