CAS 36204-23-6|Fibrinopeptide B (human) acetate salt
| Common Name | Fibrinopeptide B (human) acetate salt | ||
|---|---|---|---|
| CAS Number | 36204-23-6 | Molecular Weight | 1552.56000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C66H93N19O25 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Fibrinopeptide B |
|---|---|
| Synonym | More Synonyms |
Fibrinopeptide B (human) acetate salt BiologicalActivity
| Description | Fibrinopeptide B, human is a 14-aa peptide, released from the amino-terminus of β-chains of fibrinogen by thrombin. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Inflammation/Immunology |
| In Vitro | Fibrinopeptide B, human is released from the amino-terminus of the B 3-chains of fibrinogen by thrombin. Fibrinopeptide B, human (hFpB, 10 nM) causes directed cell migration of neutrophils (PMN), and fibroblasts. Fibrinopeptide B, human also possesses potent chemotactic activity relative to human complement (C5a), leukotriene B4 (LTB4), and formyl-methionylleucyl-phenylalanine (fMLP), and for fibroblasts its chemotactic activity is comparable to that of platelet-derived growth factor. However, Fibrinopeptide B, human is not chemotactic for monocytes, and shows no interaction with PMN receptor for C5a, LTB4, or fMLP[1]. |
| References | [1]. Senior RM, et al. Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B. J Clin Invest. 1986 Mar;77(3):1014-9. |
Chemical & Physical Properties
| Molecular Formula | C66H93N19O25 |
|---|---|
| Molecular Weight | 1552.56000 |
| Exact Mass | 1551.66000 |
| PSA | 724.91000 |
| InChIKey | MYRIFIVQGRMHRF-OECXYHNASA-N |
| SMILES | CC(NC(=O)C(CO)NC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)CNC(=O)C1CCC(=O)N1)C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)O |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles31
More Articles| Novel aspects of fibrin(ogen) fragments during inflammation. Mol. Med. 17(5-6) , 568-73, (2011) Coagulation is fundamental for the confinement of infection and/or the inflammatory response to a limited area. Under pathological inflammatory conditions such as arthritis, multiple sclerosis or seps... | |
| Fibrinopeptides A and B release in the process of surface fibrin formation. Blood 117 , 1700-1706, (2011) Fibrinogen adsorption on a surface results in the modification of its functional characteristics. Our previous studies revealed that fibrinogen adsorbs onto surfaces essentially in 2 different orienta... | |
| Fibrinogen residue γAla341 is necessary for calcium binding and 'A-a' interactions. Thromb. Haemost. 107(5) , 875-83, (2012) The fibrinogen γ-module has several important sites relating to fibrinogen function, which include the high affinity calcium binding site, hole 'a' that binds with knob 'A', and the D:D interface. Res... |
Synonyms
| pyroGlu-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg |
| Pyr-GVNDNEEGFFSAR |
| Fibrinopeptide B, human |
