| Description | Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | Sharp wave (SPW) incidence relative to baseline appears to decrease following Docosahexaenoic Acid methyl ester (DHA-Me) application[1]. There is no generation of a new protein band when bovine serum albumin (BSA) is exposed to the Fe2+ and ascorbic acid (AsA) mixed-function oxidation system in the absence of Docosahexaenoic Acid methyl ester (DHA). However, the high-molecular-weight protein band is observed after only 24 h when BSA is incubated with DHA. Incubation of BSA with 1.0 mM DHA leads to a substantial increase in protein carbonyl content and the addition of oxygen radical scavengers leads to a substantial decrease in protein carbonyl content[2]. |
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| Kinase Assay | Protein (1 mg/mL) is incubated with Docosahexaenoic Acid methyl ester (DHA) (1.0 mM) in 50 mM HEPES buffer (pH 7.4) containing 0.2% (w/v) of Tween 20 at 37°C. Mannitol, histidine, sodium benzoate, or KI is added at final concentration of 0.5 M, 0.2 M, 0.5 M, or 0.1 M, respectively. Reactive oxygen species are generated by addition of FeSO4 (1 μM) and ascorbic acid (AsA, 20 μM)[2]. |
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| References | [1]. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. [2]. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66. |
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| 4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (all-Z)- |
| fame 22:6n-3 |
| docosa-4c,7c,10c,13c,16c,19c-hexaenoic acid methyl ester |
| all-cis-4,7,10,13,16,19-docosahexaenoic acid methyl ester |
| Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate |
| 4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (4Z,7Z,10Z,13Z,16Z,19Z)- |
| Methyl (4E,7E,10E,13E,16E,19E)-4,7,10,13,16,19-docosahexaenoate |
| Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoate |
| DHA methyl ester |
| Docosahexaenoic acid methyl |
| Docosa-4c,7c,10c,13c,16c,19c-hexaensaeure-methylester |
| methyl 4,7,10,13,16,19-docosahexaenoate |
| 4,7,10,13,16,19-Docosahexaenoic acid, methyl ester, (4E,7E,10E,13E,16E,19E)- |
| all-cis-4,7,10,13,16,19-Docosahexaenoic acid methyl ester solution |
| Fame 22:6n-3,Methyl all-cis-4,7,10,13,16,19-docosahexenoate,Methyl DHA |
