CAS 161796-84-5|Esomeprazole (potassium salt)

Introduction：Basic information about CAS 161796-84-5|Esomeprazole (potassium salt), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Esomeprazole (potassium salt) BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Esomeprazole (potassium salt)
CAS Number	161796-84-5	Molecular Weight	383.50600
Density	/	Boiling Point	/
Molecular Formula	C₁₇H₁₈KN₃O₃S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	potassium,5-methoxy-2-[(S)-(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
Synonym	More Synonyms

Esomeprazole (potassium salt) BiologicalActivity

Description	Esomeprazole potassium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole potassium salt is a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Others
References	[1]. Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, et al. Physical and Chemical Stability of Esomeprazole Sodium Solutions. Ann Pharmacother. September 2008 ,42 ( 9 ):1247-1251. [2]. Esomeprazole [3]. Sandstrom M, et al. Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clin Ther. 2012 Aug;34(8):1828-38. [4]. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

Description

Esomeprazole potassium salt is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.IC50 value:Target: proton pumpEsomeprazole potassium salt is a proton pump inhibitor and gastric antisecretory agent indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagitis.

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Proton PumpResearch Areas >>Others

References

[1]. Thomas C Kupiec, Vasileios Aloumanis, Michel Ben, et al. Physical and Chemical Stability of Esomeprazole Sodium Solutions. Ann Pharmacother. September 2008 ,42 ( 9 ):1247-1251.

[2]. Esomeprazole

[3]. Sandstrom M, et al. Phase I, multicenter, randomized, open-label study evaluating the pharmacokinetics and safety profile of repeated once-daily doses of intravenous esomeprazole in children 0 to 17 years of age. Clin Ther. 2012 Aug;34(8):1828-38.

[4]. Johnson TJ, Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14):1333-9.

Chemical & Physical Properties

Molecular Formula	C₁₇H₁₈KN₃O₃S
Molecular Weight	383.50600
Exact Mass	383.07100
PSA	85.45000
LogP	3.55120
InChIKey	FOFFPEFVSRGLOZ-UHFFFAOYSA-N
SMILES	COc1ccc2[n-]c(S(=O)Cc3ncc(C)c(OC)c3C)nc2c1.[K+]
Storage condition	2-8℃

Synonyms

F37S7G37O2

Esomeprazole potassium

UNII-F37S7G37O2

Esomeprazole (potassium salt)

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