CAS 168316-95-8|Spinosad
| Common Name | Spinosad | ||
|---|---|---|---|
| CAS Number | 168316-95-8 | Molecular Weight | 734.014 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 776.3±60.0 °C at 760 mmHg |
| Molecular Formula | C42H71NO9 | Melting Point | 84ºC to 99.5ºC |
| MSDS | USA | Flash Point | 423.3±32.9 °C |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | spinosad |
|---|---|
| Synonym | More Synonyms |
Spinosad BiologicalActivity
| Description | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease |
| In Vitro | Spinosad acts as an allosteric agonist of acetylcholine (Ach) by binding to nicotinicacetylcholine receptors (nAChRs), prototypicalunits that function as neurotransmitter ligand-gated ion channels[4]. |
| In Vivo | Spinosad is a natural mixture of the pediculicidal tetracyclic macrolides spinosyn A and spinosyn D. Spinosad 0.9% mainly interferes with nicotinic acetylcholine receptors in insects, thereby producing neuronal excitation that results in paralysis of lice from neuromuscular fatigue after extended periods of hyperexcitation. Spinosad 0.9% kills both permethrin-susceptible and permethrin-resistant populations of lice. It is also ovicidal, killing both eggs (nits) and lice[5]. Spinosad causes in vivo oxidative effects in the brain of Oreochromis niloticus. Spinosad causes elevations in the contents of tGSH, GSH, GSSG, Hsp70, and reductions in the ratio of GSH/GSSG and GPx activity and an induction in the GR (glutathione reducta) activity. Spinosad has oxidative effects in the brain tissue by altering the parameters in GSH-related antioxidant system and Hsp70[6]. |
| References | [1]. Duchet C, et al. Effects of Bacillus thuringiensis israelensis and spinosad on adult emergence of the non-biting midges Polypedilum nubifer (Skuse) and Tanytarsus curticornis Kieffer (Diptera: Chironomidae) in coastal wetlands. Ecotoxicol Environ Saf. 2015;115:272-278. [2]. Wang J, et al. A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 subunit confers high-level resistance to spinosad in Plutella xylostella. Insect Biochem Mol Biol. 2016;71:29-36. [3]. Huang J, et al. High Level of Spinosad Production in the Heterologous Host Saccharopolyspora erythraea. Appl Environ Microbiol. 2016;82(18):5603-5611. Published 2016 Aug 30. [4]. McCormack PL. Spinosad: in pediculosis capitis. Am J Clin Dermatol. 2011;12(5):349-353. [5]. Santos VSV, et al. Properties, toxicity and current applications of the biolarvicide spinosad. J Toxicol Environ Health B Crit Rev. 2020;23(1):13-26. [6]. Piner P, et al. Organic insecticide spinosad causes in vivo oxidative effects in the brain of Oreochromis niloticus. Environ Toxicol. 2014;29(3):253-260. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 776.3±60.0 °C at 760 mmHg |
| Melting Point | 84ºC to 99.5ºC |
| Molecular Formula | C42H71NO9 |
| Molecular Weight | 734.014 |
| Flash Point | 423.3±32.9 °C |
| Exact Mass | 733.512878 |
| PSA | 101.99000 |
| LogP | 4.86 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.527 |
| Storage condition | 0-6°C |
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P391-P501 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | N |
| Risk Phrases | 50/53 |
| Safety Phrases | 61 |
| RIDADR | UN3077 9/PG 3 |
Synonyms
| 13-{[5-(Dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl]oxy}-9-ethyl-14-methyl-2-[(2,3,4-trimethoxy-5-methylcyclohexyl)oxy]octadecahydro-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione |
| 1H-as-Indaceno[3,2-d]oxacyclododecin-7,15-dione, 13-[[5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-9-ethyloctadecahydro-14-methyl-2-[(2,3,4-trimethoxy-5-methylcyclohexyl)oxy]- |
| Spinosyn A |
