CAS 25990-96-9|Octaethylene glycol monomethyl ether

Introduction：Basic information about CAS 25990-96-9|Octaethylene glycol monomethyl ether, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameOctaethylene glycol monomethyl ether
CAS Number25990-96-9Molecular Weight384.462
Density1.1±0.1 g/cm3Boiling Point454.0±40.0 °C at 760 mmHg
Molecular FormulaC17H36O9Melting Point/
MSDS/Flash Point228.4±27.3 °C

Names

Name2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
SynonymMore Synonyms

Octaethylene glycol monomethyl ether BiologicalActivity

DescriptionOctaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related CatalogResearch Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker
Target

PEGs

In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

Density1.1±0.1 g/cm3
Boiling Point454.0±40.0 °C at 760 mmHg
Molecular FormulaC17H36O9
Molecular Weight384.462
Flash Point228.4±27.3 °C
Exact Mass384.235931
PSA94.07000
LogP-3.30
Vapour Pressure0.0±2.5 mmHg at 25°C
Index of Refraction1.451
InChIKeySZGNWRSFHADOMY-UHFFFAOYSA-N
SMILESCOCCOCCOCCOCCOCCOCCOCCOCCO
Storage condition2-8°C

Safety Information

HS Code2909499000

Customs

HS Code2909499000
Summary2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

Synonyms

2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol
3,6,9,12,15,18,21,24-Octaoxapentacosan-1-ol
polyethylene(n ca. 8)glycol monomethyl ether
23-methoxy-3,6,9,12,15,18,21-heptaoxa-tricosan-1-ol
Octaethylene Glycol MonoMethyl Ether
O-methyl-octaethylene glycol
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