CAS 311309-27-0|Neuropeptide VF (124-131) (human) trifluoroacetate salt

Introduction：Basic information about CAS 311309-27-0|Neuropeptide VF (124-131) (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Neuropeptide VF (124-131) (human) trifluoroacetate salt
CAS Number	311309-27-0	Molecular Weight	969.14100
Density	/	Boiling Point	/
Molecular Formula	C₄₅H₇₂N₁₄O₁₀	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	h-val-pro-asn-leu-pro-gln-arg-phe-nh2
Synonym	More Synonyms

BiologicalActivity

Description	RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1].
Related Catalog	Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neuropeptide Y Receptor
In Vitro	RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM[1]. Scatchard-plot analysis shows that 125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kd value and the Bmax values are 0.19 nM and 1.3 pM, respectively. RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1]. RFRP-3 (10-8 to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].
References	[1]. Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology [2]. Iain J Clarke, et al. Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion. Endocrinology

Chemical & Physical Properties

Molecular Formula	C₄₅H₇₂N₁₄O₁₀
Molecular Weight	969.14100
Exact Mass	968.55600
PSA	403.31000
LogP	2.37640
InChIKey	JFZCLMZUABKABL-GVCDGELBSA-N
SMILES	CC(C)CC(NC(=O)C(CC(N)=O)NC(=O)C1CCCN1C(=O)C(N)C(C)C)C(=O)N1CCCC1C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(N)=O

Safety Information

Hazard Codes	Xi

Synonyms

RFRP-3 human trifluoroacetate salt

H2N-VPNLPQRF-AMIDE

V-8-F-NH2,NPVF

NPVF

V-8-F-NH2

Neuropeptide VF (124-131) (human)

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