CAS 6192-62-7|Tomatidine hydrochloride
Introduction：Basic information about CAS 6192-62-7|Tomatidine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tomatidine hydrochloride | ||
|---|---|---|---|
| CAS Number | 6192-62-7 | Molecular Weight | 452.113 |
| Density | / | Boiling Point | 551.1ºC at 760 mmHg |
| Molecular Formula | C27H46ClNO2 | Melting Point | 281-284ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | 287.1ºC |
Names
| Name | Tomatidin Hydrochloride |
|---|---|
| Synonym | More Synonyms |
Tomatidine hydrochloride BiologicalActivity
| Description | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>MAPK/ERK Pathway >>JNK |
| Target | p65 JNK |
| In Vitro | Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1]. |
| Cell Assay | RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37 °C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1]. |
| References | [1]. Chiu FL, et al. Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett. 2008 Jul 9;582(16):2407-12. |
Chemical & Physical Properties
| Boiling Point | 551.1ºC at 760 mmHg |
|---|---|
| Melting Point | 281-284ºC (dec.) |
| Molecular Formula | C27H46ClNO2 |
| Molecular Weight | 452.113 |
| Flash Point | 287.1ºC |
| Exact Mass | 451.321716 |
| PSA | 41.49000 |
| LogP | 6.49760 |
| InChIKey | SXXHVPYRDFJKPG-XRWUXUKGSA-N |
| SMILES | CC1CCC2(NC1)OC1CC3C4CCC5CC(O)CCC5(C)C4CCC3(C)C1C2C.Cl |
| Storage condition | -20℃ |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
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Synonyms
| MFCD00133866 |
| (3β,5α,25S)-Spirosolan-3-ol hydrochloride (1:1) |
| Spirosolan-3-ol, (3β,5α,25S)-, hydrochloride (1:1) |
| Tomatidine hydrochloride |
