Introduction：Basic information about CAS 137553-43-6|7-Bromoquinazoline-2,4-diamine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 7-Bromoquinazoline-2,4-diamine |
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| CAS Number | 137553-43-6 | Molecular Weight | 239.072 |
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| Density | 1.8±0.1 g/cm3 | Boiling Point | 509.4±58.0 °C at 760 mmHg |
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| Molecular Formula | C8H7BrN4 | Melting Point | 255-256°C |
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| MSDS | / | Flash Point | 261.9±32.3 °C |
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Names
| Name | 7-bromoquinazoline-2,4-diamine |
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| Synonym | More Synonyms |
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7-Bromoquinazoline-2,4-diamine BiologicalActivity
| Description | DHFR-IN-3 is a dihydrofolate reductase (DHFR) inhibitor with the IC50 values of 19 μM and 12 μM in rat liver and P. carinii DHFR, respectively[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>Antifolate |
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| References | [1]. A Rosowsky, et al. Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. Antimicrob Agents Chemother. 1995 Jan;39(1):79-86. |
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Chemical & Physical Properties
| Density | 1.8±0.1 g/cm3 |
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| Boiling Point | 509.4±58.0 °C at 760 mmHg |
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| Melting Point | 255-256°C |
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| Molecular Formula | C8H7BrN4 |
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| Molecular Weight | 239.072 |
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| Flash Point | 261.9±32.3 °C |
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| Exact Mass | 237.985397 |
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| PSA | 77.82000 |
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| LogP | 1.73 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.811 |
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| InChIKey | YPWBLOIRVSSESG-UHFFFAOYSA-N |
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| SMILES | Nc1nc(N)c2ccc(Br)cc2n1 |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2,4-Quinazolinediamine,7-bromo |
| 7-Bromo-2,4-quinazolinediamine |
| 7-bromoquinazoline-2,4-diamine |
| 2,4-Quinazolinediamine, 7-bromo- |
| 7-bromo-quinazoline-2,4-diamine |
| 7-Bromo-2,4-diaminoquinazoline |
