CAS 1665-48-1|Metaxalone
Introduction：Basic information about CAS 1665-48-1|Metaxalone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Metaxalone | ||
|---|---|---|---|
| CAS Number | 1665-48-1 | Molecular Weight | 221.252 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 453.6±14.0 °C at 760 mmHg |
| Molecular Formula | C12H15NO3 | Melting Point | 121-123ºC |
| MSDS | ChineseUSA | Flash Point | 228.2±20.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Metaxalone |
|---|---|
| Synonym | More Synonyms |
Metaxalone BiologicalActivity
| Description | Metaxalone(AHR438;NSC170959) is a muscle relaxant used to relax muscles.Target: OthersMetaxalone is a muscle relaxant used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. Its exact mechanism of action is not known, but it may be due to general central nervous system depression. It is considered to be a moderately strong muscle relaxant, with relatively low incidence of side effects. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| References | [1]. http://en.wikipedia.org/wiki/Metaxalone |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 453.6±14.0 °C at 760 mmHg |
| Melting Point | 121-123ºC |
| Molecular Formula | C12H15NO3 |
| Molecular Weight | 221.252 |
| Flash Point | 228.2±20.1 °C |
| Exact Mass | 221.105194 |
| PSA | 47.56000 |
| LogP | 2.42 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.525 |
| InChIKey | IMWZZHHPURKASS-UHFFFAOYSA-N |
| SMILES | Cc1cc(C)cc(OCC2CNC(=O)O2)c1 |
| Storage condition | -20°C Freezer |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 775 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 515 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,242,1967
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1690 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 233,326,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 490 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,261,1972
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | NONH for all modes of transport |
| RTECS | RQ3850000 |
Articles3
More Articles| Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clin. Ther. 26(9) , 1355-67, (2004) Low back pain is a leading reason for primary care visits. Many treatment options are available, but some lack scientific support.The aim of this review was to discuss the etiology of low back pain an... | |
| Development of a Stability-Indicating RP-UPLC Method for Rapid Determination of Metaxalone and its Degradation Products in Solid Oral Dosage Form. Sci. Pharm. 80(2) , 353-66, (2012) A simple, sensitive and reproducible reversed phase ultra performance liquid chromatography (RP-UPLC) coupled with a photodiode array detector method was developed for the quantitative determination o... | |
| Metaxalone (Skelaxin)-related death. J. Anal. Toxicol. 28(6) , 537-41, (2004) The case history and toxicological findings of a fatal multi-drug overdose involving metaxalone (Skelaxin) are presented. Gas-liquid chromatography with flame-ionization detection and gas chromatograp... |
Synonyms
| 5-{[(3,5-dimethylphenyl)oxy]methyl}-1,3-oxazolidin-2-one |
| 5-((3,5-Dimethylphenoxy)methyl)oxazolidin-2-one |
| Metaxalone |
| 5-[(3,5-Dimethylphenoxy)methyl]-1,3-oxazolidin-2-one |
| 5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone |
| 2-Oxazolidinone, 5-[(3,5-dimethylphenoxy)methyl]- |
| Metaxolone |
| MFCD00867700 |
| 5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone |
| Skelaxin |
| EINECS 216-777-6 |
