CAS 31008-19-2|Fargesin
Introduction：Basic information about CAS 31008-19-2|Fargesin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fargesin | ||
|---|---|---|---|
| CAS Number | 31008-19-2 | Molecular Weight | 370.396 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 506.4±50.0 °C at 760 mmHg |
| Molecular Formula | C21H22O6 | Melting Point | 132.0 to 136.0 °C |
| MSDS | / | Flash Point | 208.9±30.0 °C |
Names
| Name | fargesin |
|---|---|
| Synonym | More Synonyms |
Fargesin BiologicalActivity
| Description | Fargesin is a bioactive neolignan isolated from magnolia plants，with antihypertensive and anti-inflammatory effects[1][2][3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Others |
| In Vitro | Fargesin exhibits anti-inflammation effects on THP-1 cells via suppression of PKC pathway including downstream JNK, nuclear factors AP-1 and NF-ĸB[3]. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis[4]. |
| In Vivo | Fargesin has antihypertensive effect in 2K1C hypertensive rats via inhibiting oxidative stress and promoting NO release[1]. |
| References | [1]. Sha S, et al. Antihypertensive effects of fargesin in vitro and in vivo via attenuating oxidative stress and promoting nitric oxide release. Can J Physiol Pharmacol. 2016 Aug;94(8):900-6. [2]. Yue B, et al. Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice. Molecules. 2018 Jun 7;23(6). [3]. Pham TH, et al. Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling. Phytomedicine. 2017 Jan 15;24:96-103. [4]. Wang X, et al. Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia. 2015 Sep;105:16-25. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 506.4±50.0 °C at 760 mmHg |
| Melting Point | 132.0 to 136.0 °C |
| Molecular Formula | C21H22O6 |
| Molecular Weight | 370.396 |
| Flash Point | 208.9±30.0 °C |
| Exact Mass | 370.141632 |
| PSA | 55.38000 |
| LogP | 3.20 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.580 |
| InChIKey | AWOGQCSIVCQXBT-LATRNWQMSA-N |
| SMILES | COc1ccc(C2OCC3C(c4ccc5c(c4)OCO5)OCC23)cc1OC |
Synonyms
| Fargesin |
| 1,3-Benzodioxole, 5-[(1S,3aR,4R,6aR)-4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]- |
| 5-[(1S,3aR,4R,6aR)-4-(3,4-Dimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole |
| (+)-demethoxyaschantin |
| methyl piperitol |
| (+)-kobusin |
| Methyl pluviatilol |
| UNII:GR9853GI71 |
