Introduction：Basic information about CAS 165383-72-2|NOS-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NOS-IN-1 |
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| CAS Number | 165383-72-2 | Molecular Weight | 172.225 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C8H16N2O2 | Melting Point | 181-182ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | 2-Imino-4-methylpiperidine, Acetate |
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| Synonym | More Synonyms |
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NOS-IN-1 BiologicalActivity
| Description | NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 0.1 μM (hiNOS), 1.1 μM (heNOS), and 0.2 μM (hnNOS)[1] |
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| In Vivo | Following oral administration, NOS-IN-1 (compound 3; 10 mg/kg) decreases serum nitrite/nitrate levels in an in vivo rat endotoxin assay[1]. |
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| References | [1]. R K Webber, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101. |
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Chemical & Physical Properties
| Melting Point | 181-182ºC |
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| Molecular Formula | C8H16N2O2 |
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| Molecular Weight | 172.225 |
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| Exact Mass | 172.121185 |
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| PSA | 73.18000 |
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| LogP | 1.50260 |
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| InChIKey | QNJYWSIQJFUBOR-UHFFFAOYSA-N |
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| SMILES | CC(=O)O.CC1CCN=C(N)C1 |
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Safety Information
Customs
| HS Code | 2933399090 |
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| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Pyridinamine, 3,4,5,6-tetrahydro-4-methyl-, acetate (1:1) |
| 4-Methylpiperidin-2-imine acetate (1:1) |
| acetic acid,4-methyl-2,3,4,5-tetrahydropyridin-6-amine |
| 4-Methyl-3,4,5,6-tetrahydro-2-pyridinamine acetate (1:1) |
| 2-Piperidinimine, 4-methyl-, acetate (1:1) |
