Introduction：Basic information about CAS 163490-78-6|hnNOS-IN-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | hnNOS-IN-3 |
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| CAS Number | 163490-78-6 | Molecular Weight | 284.73 |
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| Density | 1.27 g/cm3 | Boiling Point | 322.3ºC at 760 mmHg |
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| Molecular Formula | C10H12ClF3N2S | Melting Point | 143-147ºC |
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| MSDS | / | Flash Point | 148.8ºC |
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Names
| Name | etpi hcl |
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| Synonym | More Synonyms |
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hnNOS-IN-3 BiologicalActivity
| Description | hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively[1]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Neurological Disease |
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| Target | nNOS:0.32 μM (Ki) eNOS:9.4 μM (Ki) iNOS:37 μM (Ki) |
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| References | [1]. Shearer BG, et al. Substituted N-phenylisothioureas: potent inhibitors of human nitric oxide synthase with neuronal isoform selectivity. J Med Chem. 1997 Jun 6;40(12):1901-5. |
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Chemical & Physical Properties
| Density | 1.27 g/cm3 |
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| Boiling Point | 322.3ºC at 760 mmHg |
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| Melting Point | 143-147ºC |
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| Molecular Formula | C10H12ClF3N2S |
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| Molecular Weight | 284.73 |
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| Flash Point | 148.8ºC |
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| Exact Mass | 284.036194 |
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| PSA | 61.18000 |
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| LogP | 4.77990 |
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| Vapour Pressure | 0.000281mmHg at 25°C |
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| InChIKey | UVJQIYZYQQKIAC-UHFFFAOYSA-N |
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| SMILES | CCSC(N)=Nc1ccc(C(F)(F)F)cc1.Cl |
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Safety Information
Synonyms
| Carbamimidothioic acid, N'-[4-(trifluoromethyl)phenyl]-, ethyl ester, hydrochloride (1:1) |
| TFPI HCL |
| EPIT HCL |
| MFCD01320531 |
| Ethyl N'-[4-(trifluoromethyl)phenyl]carbamimidothioate hydrochloride (1:1) |
| TFPI hydrochloride |
| SEPIT HCL |
| ETPI,HYDROCHLORIDE |
