Introduction：Basic information about CAS 169209-66-9|MTPG, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | MTPG |
|---|
| CAS Number | 169209-66-9 | Molecular Weight | 233.23 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C10H11N5O2 | Melting Point | / |
|---|
| MSDS | ChineseUSA | Flash Point | / |
|---|
Names
| Name | (±)-α-Methyl-(4-tetrazolylphenyl)glycine |
|---|
| Synonym | More Synonyms |
|---|
MTPG BiologicalActivity
| Description | MTPG is a potent mGluR2 and mGluR3 antagonist. MTPG can block the induction of brain ischemic tolerance induced by cerebral ischemic preconditioning. MTPG also significantly attenuates the inhibitory effect of L-CCG-1 on the KCl-evoked dopamine release[1]. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>mGluRResearch Areas >>Neurological Disease |
|---|
| Target | mGluR2, mGluR 3[1] |
|---|
| References | [1]. Chaki S, et al. Group II metabotropic glutamate receptor-mediated regulation of dopamine release from slices of rat nucleus accumbens. Neurosci Lett. 2006;404(1-2):182-186. [2]. Feng RF, Li WB, Liu HQ, et al. Sheng Li Xue Bao. 2003;55(3):303-310. |
|---|
Chemical & Physical Properties
| Molecular Formula | C10H11N5O2 |
|---|
| Molecular Weight | 233.23 |
|---|
| Exact Mass | 233.09100 |
|---|
| PSA | 106.92000 |
|---|
| LogP | 0.62110 |
|---|
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|
| RIDADR | NONH for all modes of transport |
|---|
| HS Code | 2933990090 |
|---|
Customs
| HS Code | 2933990090 |
|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|---|
Articles2
More Articles
| New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 , 851-856, (1995) The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2... | |
| [Effects of alpha-methyl-(4-tetrazolyl-phenyl) glycine on the induction of hippocampal ischemic tolerance in the rat]. Sheng Li Xue Bao 55 , 303-10, (2003) To explore the role of metabotropic glutamate receptor 2/3 mGluR 2/3 in the induction of brain ischemic tolerance (BIT), the influences of mGluR2/3 antagonist alpha-methyl-(4-tetrazolyl-phenyl) glycin... | |
Synonyms
| MFCD00672653 |
| 2-amino-2-[4-(tetrazol-1-yl)phenyl]propanoic acid |
