Introduction：Basic information about CAS 137592-45-1|Bisindolylmaleimide II, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Bisindolylmaleimide II |
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| CAS Number | 137592-45-1 | Molecular Weight | 438.521 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 709.9±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H26N4O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | 383.1±32.9 °C |
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Names
| Name | Bisindolylmaleimide II |
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| Synonym | More Synonyms |
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Bisindolylmaleimide II BiologicalActivity
| Description | Bisindolylmaleimide II is a general inhibitor of all PKC subtypes[1]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerResearch Areas >>Metabolic DiseaseSignaling Pathways >>TGF-beta/Smad >>PKC |
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| References | [1]. Gassel M, et al. The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A. J Biol Chem. 2004 May 28;279(22):23679-90. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 709.9±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H26N4O2 |
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| Molecular Weight | 438.521 |
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| Flash Point | 383.1±32.9 °C |
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| Exact Mass | 438.205566 |
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| PSA | 70.13000 |
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| LogP | 4.35 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.725 |
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| InChIKey | LBFDERUQORUFIN-UHFFFAOYSA-N |
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| SMILES | CN1CCCC1CCn1cc(C2=C(c3c[nH]c4ccccc34)C(=O)NC2=O)c2ccccc21 |
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Synonyms
| 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl]- |
| 3-(1H-Indol-3-yl)-4-{1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione |
| 3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl)ethyl]-1H-indol-3-yl}-1H-pyrrole-2,5-dione |
