Introduction：Basic information about CAS 136145-07-8|Arofylline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Arofylline |
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| CAS Number | 136145-07-8 | Molecular Weight | 304.73200 |
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| Density | 1.429g/cm3 | Boiling Point | 562.6ºC at 760 mmHg |
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| Molecular Formula | C14H13ClN4O2 | Melting Point | / |
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| MSDS | / | Flash Point | 294ºC |
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Names
| Name | 3-(4-chlorophenyl)-1-propyl-7H-purine-2,6-dione |
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| Synonym | More Synonyms |
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Arofylline BiologicalActivity
| Description | Arofylline is a PDE4 inhibitor as a potential treatment for asthma. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Phosphodiesterase (PDE)Research Areas >>Inflammation/Immunology |
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| References | [1]. Chorostowska-Wynimko J, Kus J, Skopińska-Rózewska E. Theophylline inhibits free oxygen radicals production by human monocytes via phosphodiesterase inhibition. J Physiol Pharmacol. 2007;58 Suppl 5(Pt 1):95-103. |
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Chemical & Physical Properties
| Density | 1.429g/cm3 |
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| Boiling Point | 562.6ºC at 760 mmHg |
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| Molecular Formula | C14H13ClN4O2 |
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| Molecular Weight | 304.73200 |
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| Flash Point | 294ºC |
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| Exact Mass | 304.07300 |
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| PSA | 72.68000 |
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| LogP | 1.93890 |
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| Vapour Pressure | 1.1E-12mmHg at 25°C |
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| Index of Refraction | 1.642 |
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| InChIKey | GVTLDPJNRVMCAL-UHFFFAOYSA-N |
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| SMILES | CCCn1c(=O)c2[nH]cnc2n(-c2ccc(Cl)cc2)c1=O |
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Synonyms
| UNII-87L38AY71R |
| 3-(4-chlorophenyl)-3,7-dihydro-1-propyl-1H-purine-2,6-dione |
| 1-n-propyl-3-(4-chlorophenyl)-xanthine |
| Arofyllin |
| 3-(4-chlorophenyl)-1-propyl-3,7-dihydro-1H-purine-2,6-dione |
| Arofylline (USAN/INN) |
| Arofylline |
| 3-(p-chlorophenyl)-1-propylxanthine |
| 3,7-dihydro-3-(4-chlorophenyl)-1-propyl-1H-purine-2,6-dione |
