CAS 3160-91-6|Moroxydine (hydrochloride)

Introduction：Basic information about CAS 3160-91-6|Moroxydine (hydrochloride), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Moroxydine (hydrochloride) BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	Moroxydine (hydrochloride)
CAS Number	3160-91-6	Molecular Weight	207.661
Density	/	Boiling Point	327ºC at 760 mmHg
Molecular Formula	C₆H₁₄ClN₅O	Melting Point	211-214ºC(lit.)
MSDS	/	Flash Point	151.6ºC

Names

Name	moroxydine hydrochloride
Synonym	More Synonyms

Moroxydine (hydrochloride) BiologicalActivity

Description	Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2].
Related Catalog	Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection
References	[1]. Sheppard, S., Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh), 1994. 183: p. 1-9. [2]. Moore, Malcolm. "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20.

Description

Moroxydine HCl is a synthetic antiviral compound chemically belonging to the series of the heterocyclic biguanidines.Target: Influenza VirusMoroxydine is an antiviral drug that was originally developed in the 1950s as an influenza treatment. It has potential applications against a number of RNA and DNA viruses [1]. Structurally moroxydine is a heterocyclic biguanidine. Moroxydine was reported in March 2014 that three kindergartens in two provinces of China had been found to be secretly dosing their students with moroxydine hydrochloride to try to prevent them from becoming ill. The kindergartens are paid only for the days that pupils attend and wanted to ensure that they maximised their earnings [2].

Related Catalog

Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection

References

[1]. Sheppard, S., Moroxydine: the story of a mislaid antiviral. Acta Derm Venereol Suppl (Stockh), 1994. 183: p. 1-9.

[2]. Moore, Malcolm. "China: All children to be given drug tests after schools caught medicating pupils". The Age. Retrieved 2014-03-20.

Chemical & Physical Properties

Boiling Point	327ºC at 760 mmHg
Melting Point	211-214ºC(lit.)
Molecular Formula	C₆H₁₄ClN₅O
Molecular Weight	207.661
Flash Point	151.6ºC
Exact Mass	207.088684
PSA	98.22000
LogP	0.76700
InChIKey	FXYZDFSNBBOHTA-UHFFFAOYSA-N
SMILES	Cl.N=C(N=C(N)N)N1CCOCC1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QD9815000

CHEMICAL NAME :: 4-Morpholinecarboxamidine, N-amidino-, monohydrochloride

CAS REGISTRY NUMBER :: 3160-91-6

LAST UPDATED :: 199501

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H13-N5-O.Cl-H

MOLECULAR WEIGHT :: 207.70

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 18,196,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 2,474,1960

Safety Information

Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-37/39
WGK Germany	3
RTECS	QD9815000
HS Code	2934999090

Customs

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

Moroxydine (hydrochloride)

4-Morpholinecarboximidoylguanidine Hydrochloride

abobhydrochloride

Moroxydine hydrochlorid

Hydrogen chloride - N-carbamimidoyl-4-morpholinecarboximidamide (1:1:1)

N-Carbamimidoyl-4-morpholinecarboximidamide chlorhydrate (1:1)

assur

Moroxydine hydrochloride

4-Morpholinecarboximidamide, N-(aminoiminomethyl)-, chloride, hydrogen salt (1:1)

N-Carbamimidoyl-4-morpholincarboximidamidhydrochlorid(1:1)

N1,N1-Anhydrobis(b-hydroxyethyl)biguanide Hydrochloride

N,N-oxapentamethylenebiguanide hydrochloride

virusmin

N-Carbamimidoyl-4-morpholinecarboximidamide hydrochloride

virustat

N1-morpholinobiguanidine hydrochloride

Miejunging

N-amidino-4-morpholincarboxamidine*hydrochloride

Malinguchlorate

Abitilguanide Hydrochloride

flumidin

1-Morpholinobiguanide Hydrochloride

N-(aminoiminomethyl)-4-morpholinecarboximidamide hydrochloride (1:1)

4-Morpholinecarboximidamide, N- (aminoiminomethyl)-, monohydrochloride

morpholinebiguanide monohydrochloride

spenitol

N-carbamimidoylmorpholine-4-carboximidamide hydrochloride

MORPHOLINO-BIUANIDE HYDROCHLORIDE

MOROXYDINE HCL

Abitylguanide Hydrochloride

N-Carbamimidoylmorpholine-4-carboximidamide hydrochloride (1:1)

morpholinebiguanidine hydrochloride

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