CAS 1689-89-0|Nitroxynil

Introduction：Basic information about CAS 1689-89-0|Nitroxynil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nitroxynil BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles25
8. Synonyms

Common Name	Nitroxynil
CAS Number	1689-89-0	Molecular Weight	290.015
Density	2.2±0.1 g/cm3	Boiling Point	280.1±40.0 °C at 760 mmHg
Molecular Formula	C₇H₃IN₂O₃	Melting Point	136 - 139ºC
MSDS	ChineseUSA	Flash Point	123.2±27.3 °C
Symbol	GHS06, GHS09	Signal Word	Danger

Names

Name	4-Hydroxy-3-iodo-5-nitrobenzonitrile
Synonym	More Synonyms

Nitroxynil BiologicalActivity

Description	Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica[1][2][3].
Related Catalog	Research Areas >>Infection
References	[1]. Holsback L, et, al. Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control. Rev Bras Parasitol Vet. Jul-Sep 2016;25(3):353-8. [2]. Takeba K, et, al. [Investigation of the residue of the fasciolicide nitroxynil in milk and dairy products]. Nihon Koshu Eisei Zasshi. 1992 Feb;39(2):75-82. [3]. Na G, et, al. A rapid colloidal gold-based immunochromatographic strip assay for monitoring nitroxynil in milk. J Sci Food Agric. 2020 Mar 30;100(5):1860-1866.

Description

Nitroxynil, anthelmintic agent, is active against parasites in both adult and immature stages. Nitroxynil is widely used for the research of infection of Fasciola hepatica[1][2][3].

Related Catalog

Research Areas >>Infection

References

[1]. Holsback L, et, al. Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control. Rev Bras Parasitol Vet. Jul-Sep 2016;25(3):353-8.

[2]. Takeba K, et, al. [Investigation of the residue of the fasciolicide nitroxynil in milk and dairy products]. Nihon Koshu Eisei Zasshi. 1992 Feb;39(2):75-82.

[3]. Na G, et, al. A rapid colloidal gold-based immunochromatographic strip assay for monitoring nitroxynil in milk. J Sci Food Agric. 2020 Mar 30;100(5):1860-1866.

Chemical & Physical Properties

Density	2.2±0.1 g/cm3
Boiling Point	280.1±40.0 °C at 760 mmHg
Melting Point	136 - 139ºC
Molecular Formula	C₇H₃IN₂O₃
Molecular Weight	290.015
Flash Point	123.2±27.3 °C
Exact Mass	289.918823
PSA	89.84000
LogP	2.80
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.736
InChIKey	SGKGVABHDAQAJO-UHFFFAOYSA-N
SMILES	N#Cc1cc(I)c(O)c([N+](=O)[O-])c1
Storage condition	0-6°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI4600000

CHEMICAL NAME :: Benzonitrile, 4-hydroxy-3-iodo-5-nitro-

CAS REGISTRY NUMBER :: 1689-89-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H3-I-N2-O3

MOLECULAR WEIGHT :: 290.02

WISWESSER LINE NOTATION :: WNR BQ CI ECN

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

Safety Information

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H315-H317-H319-H335-H400
Precautionary Statements	P261-P273-P280-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R25;R36/37/38;R43
Safety Phrases	S26-S36/37-S45
RIDADR	UN2811 6.1/PG 3
RTECS	DI4600000
HS Code	2926909090

Customs

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles25

In vitro metabolism of aromatic nitriles.

J. Pharm. Sci. 83(12) , 1729-34, (1994)

Studies on the metabolic fate of aromatic nitriles, in contrast to their aliphatic counterparts, have been minimal and the subject of controversy. The in vitro metabolic fate of several aromatic nitri...

Efficacy of an injectable combination anthelmintic (nitroxynil+clorsulon+ivermectin) against early immature Fasciola hepatica compared to triclabendazole combination flukicides given orally or topically to cattle.

Vet. Parasitol. 162(3-4) , 278-84, (2009)

The objective was to compare the efficacy against artificially induced 2- and 4-week old early immature triclabendazole-susceptible liver flukes (Fasciola hepatica) of an injectable combination of nit...

Determination of nitroxynil residues in tissues using high-performance liquid chromatography-thermospray mass spectrometry.

Analyst 114(9) , 1013-5, (1989)

A method is described for the determination of nitroxynil residues in muscle, liver and kidney. The samples were extracted into diethyl ether and cleaned-up using a simple liquid-liquid extraction ste...

Synonyms

MFCD00070776

Dovenix

Nitroxynil

Benzonitrile, 4-hydroxy-3-iodo-5-nitro-

4-Hydroxy-3-iodo-5-nitrobenzonitrile

EINECS 216-884-8

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